Evidence map›Paper›PMID 40711170›Full record

ArticleToxins2025

The Dissociation of Latrophilin Fragments by Perfluorooctanoic Acid (PFOA) Inhibits LTX

Evelina Petitto, Jennifer K Blackburn, M Atiqur Rahman, Yuri A Ushkaryov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. The Mechanism of LTXInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Evelina PetittoMedway School of Pharmacy, University of Kent, Chatham ME4 4TB, UK.
Jennifer K BlackburnMedway School of Pharmacy, University of Kent, Chatham ME4 4TB, UK.ORCID 0000-0002-2171-6716
M Atiqur RahmanDepartment of Life Sciences, Imperial College London, London SW7 2AZ, UK.
Yuri A UshkaryovMedway School of Pharmacy, University of Kent, Chatham ME4 4TB, UK.ORCID 0000-0002-5712-8297

Funding

Biotechnology and Biological Science Research Council 28/B14085Biotechnology and Biological Science Research Council BB/D523078/1Wellcome TrustWellcome Trust GR074359
6 · The paper itself

Abstract

α-Latrotoxin stimulates neurotransmitter release by binding to a presynaptic receptor and then forming ion-permeable membrane pores and/or stimulating the receptor, latrophilin-1, or Adhesion G-protein-coupled receptor type L1 (ADGRL1). To avoid pore formation, we use the mutant α-latrotoxin (LTX

Indexed as

CaprylatesFluorocarbonsNeurotransmitter AgentsReceptors, PeptideSpider VenomsAnimalsCell Line, TumorHumansMicealpha-latrotoxinalpha-latrotoxin receptorCaprylatesFluorocarbonsNeurotransmitter Agentsperfluorooctanoic acidReceptors, PeptideSpider VenomsADGRL1exocytosisinhibitionlatrophilin-1LTXN4Cneuromuscular junctionneurotransmitter releaseperfluorooctanoic acid (PFOA)α-Latrotoxin

Identifiers

PMID40711170
PMCPMC12300799

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.