ArticleEpilepsia2025
Long-term survival after adult epilepsy surgery: Mortality and predictors in a large cohort.
Article in Epilepsia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Left Peripheral Nerve Palsy after Left Anterior Temporal Lobectomy for Mesial Temporal Sclerosis.Journal of neurological surgery reports · 2026Article
- SUDEP update 2026: recent advances in experimental and clinical research.Current opinion in neurology · 2026Review
- Current perspectives in sudden unexpected death in epilepsy (SUDEP): epidemiology, research approaches and pathways to prevention.Neurological research and practice · 2026Review
- Long-term survival after adult epilepsy surgery: Mortality and predictors in a large cohort.Epilepsia · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectiveLong-term survival data in adults undergoing surgery for drug-resistant focal epilepsy remain limited. We examined mortality patterns and predictors in a large cohort followed for over 30 years.
methodsAdults who underwent epilepsy surgery (1990-2022) were analyzed. Prospectively collected clinical, surgical, and outcome data were included. We estimated the cumulative incidence of mortality and standardized mortality ratios (SMRs) for the cohort. Predictors of epilepsy-related and non-epilepsy-related deaths were identified using Fine-Gray and cause-specific hazard models.
resultsA total of 1062 individuals contributed 14 279 person-years of follow-up (median, 13 years). The overall mortality rate was 6.16 per 1000 person-years, with 2.52 per 1000 person-years due to epilepsy-related deaths, including 0.84 per 1000 person-years from sudden unexpected death in epilepsy (SUDEP). Epilepsy-related deaths were more frequent within the first 15 years post-surgery (p = 0.006). The overall SMR was 1.12 (95% confidence interval [CI]: 0.90-1.38), and 0.65 (95% CI: 0.46-0.89) among individuals followed for more than 15 years. Independent predictors of epilepsy-related mortality were older age at surgery, cortical malformations, and poor post-operative seizure control (International League Against Epilepsy [ILAE] outcome class ≥4). Non-epilepsy-related mortality was driven primarily by older age at surgery. SIGNIFICANCE: Epilepsy surgery is associated with reduced premature mortality and increasingly normalized long-term survival. Age at surgery, post-operative seizure control, and pathological findings are key determinants of survival, highlighting opportunities to improve surgical outcomes further.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.