Evidence map›Paper›PMID 40711642›Full record

ArticleMedical oncology (Northwood, London, England)2025

Ephrin B3 drives tumorigenesis and inflammation in cutaneous squamous cell carcinoma.

Naixin Kang, Zhe Wang, Ying Feng, Ruinan Zhao, Min Liao, Zhen Qiao, Dan Li, Shu Pan, Qiongming Xu, Guoqiang Xu and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Medical oncology (Northwood, London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Naixin KangDepartment of Pharmacognosy, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, Jiangsu, China.
Zhe WangSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, China.
Ying FengDepartment of Pharmacognosy, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, Jiangsu, China.
Ruinan ZhaoDepartment of Pharmacognosy, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, Jiangsu, China.
Min LiaoDepartment of Pharmacognosy, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, Jiangsu, China.
Zhen QiaoDepartment of Pharmacognosy, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, Jiangsu, China.
Dan LiDepartment of Pharmacognosy, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, Jiangsu, China.
Shu PanWuXi AppTec (Suzhou) Co., Ltd, Suzhou, China.
Qiongming XuDepartment of Pharmacognosy, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, Jiangsu, China.
Guoqiang XuDepartment of Pharmacognosy, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, Jiangsu, China.
Suya SunDepartment of Neurology, Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Nanjie XuDepartment of Anatomy, Histology and Embryology, Neuroscience Division, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Miaoxia HeDepartment of Pathology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. hmm26@163.com.
Suxiang FengAcademy of Chinese Medicine Sciences, Henan University of Chinese Medicine, Zhengzhou, 450018, Henan, China. fengsx221@163.com.
Yanli LiuDepartment of Pharmacognosy, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, Jiangsu, China. liuyanli@suda.edu.cn.

Funding

National Natural Science Foundation of China 81903896
6 · The paper itself

Abstract

Dysregulation of Eph receptor-ephrin signaling contributes to tumorigenesis, yet the specific role of Ephrin B3 in cutaneous squamous cell carcinoma (cSCC) remains poorly understood. This study identifies Ephrin B3 as a critical oncogenic driver in cSCC, demonstrating its significant overexpression in cSCC tissues and association with poor prognosis. To elucidate its tumor-promoting mechanisms, we generated Ephrin B3 knockout (Efnb3

Indexed as

CarcinogenesisCarcinoma, Squamous CellEphrin-B3InflammationSkin NeoplasmsAnimalsCell Line, TumorCell MovementCell ProliferationHumansKeratin-19MiceMice, Inbred C57BLMice, KnockoutSignal TransductionEphrin-B3Keratin-19CK19Cutaneous squamous cell carcinomaEphrin B3InflammationTumorigenesis

Identifiers

PMID40711642

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.