Evidence map›Paper›PMID 40711680›Full record

Trial reportAIDS and behavior2025

Resistance Training Improves Cognitive Function and Depression Without Changing BDNF Levels in People Living with HIV: a Randomized Controlled Clinical Trial.

Dayane Cristina de Souza, Kauana Borges Marchini, Pollyana Mayara Nunhes, Wagner Jorge Rodrigues Domingues, Dennis Armando Bertolini, Vitor Oliveira, Oldemar Mazzardo, Ademar Avelar

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in AIDS and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03879993 (Effects of Resistance Training in People Living With HIV/AIDS), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03879993 nacompletednot on this map

Effects of Resistance Training in People Living With HIV/AIDS

TypeinterventionalSponsorState University of MaringáRan2018 to 2019Enrolled49ConditionsHIV/AIDSArmsExercise group
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dayane Cristina de SouzaCollegiate of Physical Education, State University of Western Paraná, Marechal Cândido Rondon, Paraná, Brazil. daynycs@gmail.com.ORCID http://orcid.org/0000-0003-4552-6500
Kauana Borges MarchiniDepartment of Physical Education, State University of Maringa, Maringá, Paraná, Brazil.ORCID https://orcid.org/0000-0002-8968-9355
Pollyana Mayara NunhesDepartment of Physical Education, State University of Maringa, Maringá, Paraná, Brazil.ORCID https://orcid.org/0000-0001-8162-0866
Wagner Jorge Rodrigues DominguesGraduate Program in Operational Human Performance, Air Force University, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0003-1638-6465
Dennis Armando BertoliniDepartment of Clinical Analysis and Biomedicine, State University of Maringa, Maringa, Paraná, Brazil.ORCID http://orcid.org/0000-0002-6460-7560
Vitor OliveiraDepartment of Child, Family and Population Health Nursing, University of Washington, Seattle, USA.
Oldemar MazzardoCollegiate of Physical Education, State University of Western Paraná, Marechal Cândido Rondon, Paraná, Brazil.ORCID http://orcid.org/0000-0001-5325-9815
Ademar AvelarDepartment of Physical Education, State University of Maringa, Maringá, Paraná, Brazil.ORCID http://orcid.org/0000-0002-9562-7230

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001
6 · The paper itself

Abstract

The increased life expectancy provided by Antiretroviral Therapy(ART) has led to the incidence of different comorbidities in people living with the Human Immunodeficiency Virus (HIV), especially comorbidities related to aging and mental health. Among these, cognitive impairment and depression increased in this population. Therefore, non-pharmacological strategies, such as physical exercise, have been studied to improve these outcomes. This study aimed to investigate the effects of eight weeks of resistance training(RT) on cognitive function and depression status in people with HIV. The sample consisted of 20 subjects (12 men and eight women), randomized in two groups: Control Group (CG, n = 9) and Training Group (TG, n = 11). Cognitive function (Stroop Test), depression status (Beck Depression Inventory- BDI), and plasma levels of Brain-Derived Neurotrophic Factor (BDNF) were assessed before and after the resistance training intervention. The results indicated thatRT was able to promote significant improvements in the cognitive domains and reduce symptoms of depression (ΔCG: 1.56 ± 2.46; ΔTG -3.18 ± 1.66, P > 0.001). Regarding BDNF, no significant change was observed (P > 0.05). In conclusion, eight weeks ofRT improves cognitive function and depression status in people with HIV, without changing the circulating BDNF levels (NCT03879993).

Indexed as

Brain-Derived Neurotrophic FactorCognitionDepressionHIV InfectionsResistance TrainingAdultFemaleHumansMaleMiddle AgedPsychiatric Status Rating ScalesTreatment OutcomeBDNF protein, humanBrain-Derived Neurotrophic FactorAcquired immunodeficiency syndromeCognitionMental healthPhysical exercise

Identifiers

PMID40711680

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.