Evidence mapPaperPMID 40711682Full record

ReviewInflammopharmacology2025

Recent advancement in molecular pathways and receptor targeting using natural products for wound healing activity.

Ankita Sinha, Parag Jain, Ajazuddin

Abstract readReview
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In one paragraph

Review in Inflammopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Synergistic COInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ankita SinhaDepartment of Pharmacology, Rungta College of Pharmaceutical Science and Research, Bhilai, Chhattisgarh, India.
Parag JainDepartment of Pharmacology, Rungta College of Pharmaceutical Science and Research, Bhilai, Chhattisgarh, India. paragjain1510@gmail.com.ORCID http://orcid.org/0000-0001-9013-9839
AjazuddinDepartment of Pharmacology, Rungta College of Pharmaceutical Science and Research, Bhilai, Chhattisgarh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wound healing is a physiological process that has multiple phases of inflammation, proliferation, and remodeling that all need to be conducted in a coordinated manner by different cell types, cytokines, and signalling pathways. Recent developments in herbal medicine have shown the therapeutic potential of natural compounds in the augmentation of wound healing by regulation of molecular pathways and receptor targets. This narrative review addresses the wound healing role of herbal medicine using specific examples of growth factor receptors such as Epidermal Growth Factor Receptor, Transforming Growth Factor-β Receptor, Vascular Endothelial Growth Factor Receptor, and Fibroblast Growth Factor Receptor. Immune receptors including Toll-like Receptors and NOD-like Receptors are also involved in regulation of inflammation and immune response during wound healing. In addition, the review addresses the role of neurotransmitter receptors in pain relief and healing of wounds. Some of the herbal extracts, including Aloe vera, Calendula officinalis, Curcuma longa, honey, and Centella asiatica, have shown very good wound-healing activity owing to their antioxidant, anti-inflammatory, and antimicrobial properties. The comparative analysis of plant-derived and animal-derived natural drugs also focuses on their curative potency in wound healing. Thus, information regarding molecular mechanisms associated with the use of herbal medicine in wound healing may help in the development of novel therapeutic strategies for chronic and non-healing wounds.

Indexed as

Biological ProductsSignal TransductionWound HealingAnimalsAnti-Inflammatory AgentsHumansInflammationPhytotherapyPlant ExtractsAnti-Inflammatory AgentsBiological ProductsPlant ExtractsInflammationMedicinal plantsMolecular pathwayReceptorSignallingWound

Identifiers

PMID40711682

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.