ArticleNeuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater2025
Predictive model for mild cognitive impairment in older Chinese adults with depression.
Article in Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Scalable CT-based prognostic modeling of dementia conversion in mild cognitive impairment.Scientific reports · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundOlder adults with depression are at an increased risk of developing cognitive decline. This study aimed to develop and validate a risk prediction model for mild cognitive impairment (MCI) in older adults with depression in China.
methodsThis study used 2020 China Health and Retirement Longitudinal Study (CHARLS) data, splitting the cohort (70:30) into training and validation sets. Least absolute shrinkage and selection operator (LASSO) regression with ten-fold cross-validation identified key predictors, and binary logistic regression examined MCI risk factors in older adults with depression. A nomogram was developed, with receiver operating characteristic (ROC) curves assessing discrimination, calibration curves for accuracy, and decision curve analysis (DCA) for clinical benefit.
resultsThis study included 3512 older adults with depression, 640 (19.9%) of whom had MCI. Binary logistic regression identified age, education level, marital status, residence, pain, internet use, and social participation as significant predictors of MCI in older adults with depression, and these factors were used to construct a nomogram model with good consistency and predictive accuracy. The area under the curve (AUC) values of the predictive model in the training set and internal validation set were 0.78 (95% confidence interval [CI] 0.75-0.80) and 0.75 (95% CI 0.71-0.78); the Hosmer-Lemeshow test results were P = 0.916 and P = 0.749, respectively. ROC analysis of the prediction model showed strong discriminatory ability, calibration curves demonstrated significant agreement between the nomogram model and actual observations, and DCA confirmed a favorable net benefit.
conclusionThe nomogram constructed in this study is a promising and convenient tool for evaluating the risk of MCI among older adults with depression, facilitating early identification of high-risk individuals and enabling timely intervention.
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Registered trials
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