ArticleMacromolecular rapid communications2025
Self-Immolative Polyion Complexes.
Article in Macromolecular rapid communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Self-Immolative Polyion Complexes.Macromolecular rapid communications · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Polyion complex (PICs) micelles are formed through the self-assembly of polyelectrolytes bearing opposite charges. The ability to form PICs under fully aqueous conditions makes them attractive for the encapsulation of biopolymers such as proteins and nucleic acids for potential therapeutic applications. Stimuli-responsive PIC micelles have the potential to release their cargo under specific biological conditions. We describe here the development of PIC micelles formed from two self-immolative polymers (SIPs) with complementary charges. The polycationic SIP, having pendent ammonium groups, undergoes depolymerization in response to light. The polyanionic SIP, bearing pendent carboxylates and a stabilizing PEG block, undergoes depolymerization in response to a pH change from 7.4 to 6. SIP PICs composed of a 0.6 anion:cation ratio remain well dispersed at pH 7.4, but degrade at pH 6, primarily due to depolymerization of the anionic block. Irradiation with UV light leads primarily to depolymerization of the cationic block. In vitro cytotoxicity assays with C2C12 cells indicate that the PICs are quite well tolerated by the cells with low cytotoxicity up to about 0.5 mg mL
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.