ReviewScience advances2025
DAMPs cross-talk interpretation of MDD mechanisms.
Review in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- SCTR-Expressing Astrocyte-Serotonergic Neuron Signaling Drives Sexual Dimorphism in Depression Through KAT7/H4ac-Foxc2 Epigenetic Axis in an AMPK-Dependent Manner.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Distinct cytokine-producing dendritic cell profiles in females and males with major depressive disorder.Frontiers in cellular neuroscience · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The incidence rate, disability rate, and suicide rate of major depressive disorder (MDD) are increasing year by year, but the mechanism has not yet been clarified. There are multiple hypotheses about the etiology of MDD, among which the cross-talk between the immune system and the nervous system breaks the boundaries between neurologic and psychiatric disorders and provides a breakthrough in the etiologic study of MDD. Combining the immunological "danger theory," inflammation triggered by damage-associated molecular patterns (DAMPs) produced by the central nervous system (CNS) and the immune system may be the underlying cause of MDD; however, MDD has not yet been explored in depth from this perspective. This work reviewed the cross-talk of DAMPs between the CNS and the immune system, suggesting that stress-induced CNS inflammation is an important pathogenetic mechanism of MDD, and the cross-talk of DAMPs is a central factor, refining the hypothesis of the etiology of MDD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.