Evidence mapPaperPMID 40712083Full record

ArticleChemical research in toxicology2025

Aetokthonotoxin, the Causative Agent of Vacuolar Myelinopathy, Uncouples Oxidative Phosphorylation due to Protonophore Activity.

Valerie I C Rebhahn, Mohamad Saoud, Mathias Winterhalter, Franziska Schanbacher, Maximilian Jobst, Rebeca Ruiz, Alexander Sonntag, Johannes Kollatz, Rieke Sprengel, Stephen F Donovan and 3 more

Abstract read
In one paragraph

Article in Chemical research in toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Valerie I C RebhahnInstitute of Pharmacy, Pharmaceutical Biology, Freie Universität Berlin, 14195 Berlin, Germany.ORCID 0000-0003-1527-6299
Mohamad SaoudDepartment of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, 06120 Halle (Saale), Germany.
Mathias WinterhalterSchool of Science, Constructor University Bremen gGmbH, Bremen 28759, Germany.
Franziska SchanbacherInstitute of Pharmacy, Pharmaceutical Biology, Freie Universität Berlin, 14195 Berlin, Germany.ORCID 0009-0005-8750-6454
Maximilian JobstDepartment of Food Chemistry and Toxicology, Core Facility Multimodal Imaging, Faculty of Chemistry, University of Vienna, Vienna 1090, Austria.
Rebeca RuizPion Inc., Forest Row Business Park, Forest Row RH18 5DW, United Kingdom.
Alexander SonntagInstitute of Pharmacy, Pharmaceutical Biology, Freie Universität Berlin, 14195 Berlin, Germany.ORCID 0000-0002-1755-3379
Johannes KollatzInstitute of Pharmacy, Pharmaceutical Biology, Freie Universität Berlin, 14195 Berlin, Germany.
Rieke SprengelInstitute of Pharmacy, Pharmaceutical Biology, Freie Universität Berlin, 14195 Berlin, Germany.
Stephen F Donovan
Giorgia Del FaveroDepartment of Food Chemistry and Toxicology, Core Facility Multimodal Imaging, Faculty of Chemistry, University of Vienna, Vienna 1090, Austria.ORCID 0000-0001-8633-5458
Robert RennertDepartment of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, 06120 Halle (Saale), Germany.
Timo H J NiedermeyerInstitute of Pharmacy, Pharmaceutical Biology, Freie Universität Berlin, 14195 Berlin, Germany.ORCID 0000-0003-1779-7899

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aetokthonotoxin (AETX) is an emerging environmental toxin produced by the freshwater cyanobacterium

Indexed as

Bacterial ToxinsOxidative PhosphorylationVacuolesAnimalsCyanobacteriaCyanobacteria ToxinsHumansIndolesMembrane Potential, MitochondrialMitochondriaOxygen ConsumptionProtonsaetokthonotoxinBacterial ToxinsCyanobacteria ToxinsIndolesProtons

Identifiers

PMID40712083
PMCPMC12442230

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.