Evidence map›Paper›PMID 40712141›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

A Human Immuno-Lung Organoid Model to Study Macrophage-Mediated Lung Cell Senescence Upon SARS-CoV-2 Infection.

Yuling Han, Dongliang Leng, Tuo Zhang, Jian Ge, Yinshan Fang, Tiankun Lu, Xue Dong, Manoj S Nair, Neranjan de Silva, Zhaowei Han and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Organoids for disease modeling and treatment: state-of-the-art.Experimental hematology & oncology · 2026
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Yuling HanDepartment of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA.
Dongliang LengDepartment of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA.
Tuo ZhangGenomic Resource Core Facility, Weill Cornell Medicine, New York, NY, 10065, USA.
Jian GeColumbia Center for Human Development and Division of Digestive and Liver Disease, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University IrvingMedical Center, New York, NY, 10032, USA.
Yinshan FangColumbia Center for Human Development and Division of Digestive and Liver Disease, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University IrvingMedical Center, New York, NY, 10032, USA.
Tiankun LuDepartment of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA.
Xue DongDepartment of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA.
Manoj S NairAaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, 10032, USA.
Neranjan de SilvaDepartment of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA.
Zhaowei HanGilbert S. Omenn Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA.
Tiancheng JiaoGilbert S. Omenn Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA.
Yuanhao HuangGilbert S. Omenn Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA.
Meiqi ZhaoGilbert S. Omenn Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA.
Anjali SaqiDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Hanina HibshooshDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Zihe MengDepartment of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA.
Jenny Z XiangGenomic Resource Core Facility, Weill Cornell Medicine, New York, NY, 10065, USA.
Chendong PanGenomic Resource Core Facility, Weill Cornell Medicine, New York, NY, 10065, USA.
Yanjie SunGenomic Resource Core Facility, Weill Cornell Medicine, New York, NY, 10065, USA.
David D HoAaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, 10032, USA.
Todd EvansDepartment of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA.
Jie LiuGilbert S. Omenn Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA.
Liuliu YangDepartment of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA.
Jianwen QueColumbia Center for Human Development and Division of Digestive and Liver Disease, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University IrvingMedical Center, New York, NY, 10032, USA.
Shuibing ChenDepartment of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA.ORCID https://orcid.org/0000-0002-6294-5187

Funding

Improve Lung Regeneration Through Targeting Tuft Cells Following Viral InfectionR01HL159675 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUE, JIANWEN · 2021 to 2024
$2.4M
VEGF/KDR Signaling in Airway Epithelial Regeneration and DiseaseR01HL152293 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUE, JIANWEN · 2021 to 2024
$2.0M
Posttranscriptional modification in lung development and regenerationR01HL179522 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUE, JIANWEN · 2025 to 2025
$769k
Department of Defense W81XWH-21-1-0196Department of Surgery, Weill Cornell MedicineGates Foundation INV-037420NHLBI NIH HHS 1R01HL152293NHLBI NIH HHS R01 HL152293NHLBI NIH HHS R01 HL159675NHLBI NIH HHS R01HL159675NHLBI NIH HHS R01 HL179522NHLBI NIH HHS R01HL179522
6 · The paper itself

Abstract

While COVID-19 affects multiple organ systems, the human respiratory system is the primary viral target and main site for disease progression. In this study, spatial transcriptional assays (NanoString CosMx) are utilized to analyze both explant and autopsy samples from non-COVID and COVID-19 lungs, identifying the activation of proinflammatory macrophages in COVID-19 explants. It is further developed immuno-lung organoids comprising hPSC-derived alveolar and airway organoids co-cultured with macrophages to investigate the impact and underlying mechanisms of macrophage-mediated lung damage following SARS-CoV-2 infection. The findings demonstrate that proinflammatory macrophages induce lung cell senescence through the THBS1-(ITGA3+ITGB1) signaling axis, a mechanism further validated using spatial transcriptomics. This study not only establishes physiologically relevant immuno-lung organoid models for modeling macrophage-mediated tissue damage, but also identifies a previous unrecognized role of the THBS1-(ITGA3+ITGB1) pathway in driving lung cell senescence during infectious disease.

Indexed as

Cellular SenescenceCOVID-19LungMacrophagesOrganoidsHumansSARS-CoV-2Thrombospondin 1Thrombospondin 1macrophageorganoidspatial transcriptomics

Identifiers

PMID40712141
PMCPMC12463091

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.