Evidence map›Paper›PMID 40713245›Full record

ArticleThe journal of prevention of Alzheimer's disease2025

Dietary sugar intake, genetic susceptibility, and risk of dementia: A prospective cohort study.

Yu An, Limin Cao, Gang Zheng, Yashu Liu, Honghao Yang, Liangkai Chen, Yuhong Zhao, Xiaopeng Zhang, Yang Xia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of prevention of Alzheimer's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yu AnMedical Research Center, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, 100020, Beijing, China.
Limin CaoThe Third Central Hospital of Tianjin, No. 83, Jin Tang Road, Tianjin, 300070, China.
Gang ZhengDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, No. 36, San Hao Street, Shenyang, Liaoning, 110004, China; Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, Shenyang, No. 36, San Hao Street, Shenyang, Liaoning, 110004, China.
Yashu LiuDepartment of General Surgery, Shengjing Hospital of China Medical University, Shenyang, No. 36, San Hao Street, Shenyang, Liaoning, 110004, China.
Honghao YangDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, No. 36, San Hao Street, Shenyang, Liaoning, 110004, China; Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, Shenyang, No. 36, San Hao Street, Shenyang, Liaoning, 110004, China.
Liangkai ChenDepartment of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13, Hang Kong Road, 430030, Wuhan, China.
Yuhong ZhaoDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, No. 36, San Hao Street, Shenyang, Liaoning, 110004, China; Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, Shenyang, No. 36, San Hao Street, Shenyang, Liaoning, 110004, China.
Xiaopeng ZhangKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Gastrointestinal Cancer Center, Peking University Cancer Hospital and Institute, Beijing 100142, China. Electronic address: xiaopeng.zhang@bjmu.edu.cn.
Yang XiaDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, No. 36, San Hao Street, Shenyang, Liaoning, 110004, China; Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, Shenyang, No. 36, San Hao Street, Shenyang, Liaoning, 110004, China; Department of Data Center, Shengjing Hospital of China Medical University, Shenyang, No. 36, San Hao Street, Shenyang, Liaoning, 110004, China.. Electronic address: xytmu507@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSugar intake has been identified as a risk factor for incident dementia; however, the role of genetic susceptibility in such association remains unclear.

methodsThis cohort study involved 158,408 participants from the UK Biobank to explore the effect of genetic susceptibility on the association between dietary sugar intake and dementia risk. Data on sugar intake were evaluated using repeated web-based 24-hour dietary recalls. Polygenic risk scores (PRS) for sugar metabolism (Triglyceride Glucose, TyG), gut microbiota, and disease susceptibility (Alzheimer's disease) were generated based on genome-wide association studies.

resultsOver a median follow-up period of 9.94 years, 1,219 dementia cases (0.7%) were documented. There were significant positive dose-response relationships between sugar intake and dementia risk (non-free sugar: HR, 95% CI,

conclusionBoth free and non-free sugar intake are independent risk factors for dementia incidence. The role of genetic susceptibility among such association cannot be ignored. These results underscore the importance of personalized nutritional interventions targeting both dietary habits and genetic risk profiles in dementia prevention strategies.

Indexed as

DementiaDietary SugarsGenetic Predisposition to DiseaseAgedCohort StudiesFemaleGastrointestinal MicrobiomeGenome-Wide Association StudyHumansMaleMiddle AgedProspective StudiesRisk FactorsUnited KingdomDietary SugarsCohortDementiaGenetic susceptibilityGut microbiotaNon-free sugar intake

Identifiers

PMID40713245
PMCPMC12501323

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.