Evidence map›Paper›PMID 40713478›Full record

ArticleBMC genomics2025

Temporal dynamics of chicken host's molecular response against Fowl adenovirus serotype 8b infection via RNA-sequencing.

Bahiyah Azli, Nur Farhana Salim, Mohd Hair-Bejo, Abdul Rahman Omar, Norfitriah Mohamed Sohaimi, Ugwu Chidozie Clifford, Nor Asilah Wati Abdul Hamid, Nurulfiza Mat Isa

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In one paragraph

Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bahiyah AzliLaboratory of Vaccine and Biomolecules, Institute of Bioscience, Universiti Putra, putrajaya, Malaysia.
Nur Farhana SalimLaboratory of Vaccine and Biomolecules, Institute of Bioscience, Universiti Putra, putrajaya, Malaysia.
Mohd Hair-BejoLaboratory of Vaccine and Biomolecules, Institute of Bioscience, Universiti Putra, putrajaya, Malaysia.
Abdul Rahman OmarLaboratory of Vaccine and Biomolecules, Institute of Bioscience, Universiti Putra, putrajaya, Malaysia.
Norfitriah Mohamed SohaimiLaboratory of Vaccine and Biomolecules, Institute of Bioscience, Universiti Putra, putrajaya, Malaysia.
Ugwu Chidozie CliffordDepartment of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, 43400, Malaysia.
Nor Asilah Wati Abdul HamidDepartment of Communication Technology and Network, Faculty of Computer Science and Information Technology, Universiti Putra Malaysia, Serdang, 43400, Malaysia.
Nurulfiza Mat IsaLaboratory of Vaccine and Biomolecules, Institute of Bioscience, Universiti Putra, putrajaya, Malaysia. nurulfiza@upm.edu.my.

Funding

Ministry of Higher Education, Malaysia 5220002Universiti Putra Malaysia 9705400
6 · The paper itself

Abstract

backgroundFowl adenovirus serotype 8b (FAdV-8b) is the etiological agent of inclusion body hepatitis' outbreaks in chicken farms worldwide and a threat to the poultry industry. The isolation and identification of isolates of this pathogen are abundant, yet the pathogenesis and subsequent molecular mechanism are significantly understudied. Hence, this study aims to identify the differential gene expression profile of specific pathogen-free chicken livers infected with FAdV-8b strain UPMT1901 isolate.

resultsThe harvested chicken livers were subjected to biological pooling and transcriptomic profiling via RNA-sequencing, according to the days of post-infections (dpi). A total of 21,662 genes were identified in both control and infected groups, enriched in various biological processes and pathways, displaying patterns of disease progressions. The transcriptome analysis results revealed a three-fold reduced pattern of gene regulation with 9146, 7335, and 3800 significant differential expressed genes (DEGs) at 2-, 5-, and 7-dpi (dpi), respectively.

conclusionThese findings elucidate insights on the holistic disease progression of FAdV-8b in liver, from viral incubation and replication at 0-2-dpi, major metabolite hijacking at 3-5-dpi, followed by constant regulation of immune response at 6- and 7-dpi. Based on intensive literature review conducted prior to this study, this study is considered as the first study of the serotype 8b infection pathogenesis at the target organ, providing a better understanding and wide basis of pathogen-host interaction in FAdV-8b in chickens and its progression.

Indexed as

Adenoviridae InfectionsAviadenovirusChickensHost-Pathogen InteractionsPoultry DiseasesAnimalsGene Expression ProfilingLiverSequence Analysis, RNASerogroupTranscriptomeAvianDisease progressionFowl adenovirusHost responseInclusion body hepatitisRNA-SequencingTemporalTranscriptomic

Identifiers

PMID40713478
PMCPMC12291256

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.