ArticleBMC musculoskeletal disorders2025
Identification the correlation between hip and knee osteoarthritis and their causal relationship with immune traits.
Article in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- The Osteoimmunologic Basis of Biologic and Bioengineered Therapies in Osteoarthritis.Biomedicines · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteoarthritis (OA), wherever affecting the hip or knee, is the most commonly diagnosed degenerative joint disorder. However, the relationship between hip osteoarthritis (HOA) and knee osteoarthritis (KOA) remains unclear. Moreover, their specific associations with immune traits also remain unclear.
methodUsing two-sample Mendelian randomization (MR) analysis, the association between HOA and KOA was comprehensively assessed. To investigate the relationship between immune traits and HOA/KOA, forward MR analysis treated immune traits as the exposure and HOA/KOA as the outcome, Conversely, reverse MR analysis treated HOA/KOA as the exposure and immune phenotypes as the outcome. After adjusting for the false discovery rate, significant statistical associations were identified among KOA and HOA, KOA and immune traits, and HOA and immune traits.
resultsThe analysis revealed a causal relationship between KOA and HOA, with each increasing the risk of the other. Additionally, several identified immune traits were found to serve as independent factors on KOA and HOA. Specifically, KOA was associated with CD25 on IgD + CD24+, while HOA was associated with CD20 on memory B cells and PDL-1 on CD14- CD16 + monocytes.
conclusionThis study provides the first comprehensive evaluation of the interactions between HOA, KOA, and immune responses. These findings offer novel insights into the pathogenesis of HOA and KOA, and suggest potential therapeutic strategies, such as targeting immunological pathways.
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