Evidence map›Paper›PMID 40713640›Full record

ArticleCell communication and signaling : CCS2025

Silencing P2Y

Catarina Bessa-Andrês, Rui Pinto-Cardoso, Maria Adelina Costa, Fátima Ferreirinha, José Marinhas, Rolando Freitas, Rui Lemos, Diogo Catelas, Adélio Vilaça, António Oliveira and 2 more

Abstract read
In one paragraph

Article in Cell communication and signaling : CCS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Catarina Bessa-AndrêsLaboratório de Farmacologia e Neurobiologia, Instituto de Ciências Biomédicas Abel Salazar - Universidade do Porto (ICBAS-UP), Porto, 4050-313, Portugal.
Rui Pinto-CardosoLaboratório de Farmacologia e Neurobiologia, Instituto de Ciências Biomédicas Abel Salazar - Universidade do Porto (ICBAS-UP), Porto, 4050-313, Portugal.
Maria Adelina CostaLaboratório de Farmacologia e Neurobiologia, Instituto de Ciências Biomédicas Abel Salazar - Universidade do Porto (ICBAS-UP), Porto, 4050-313, Portugal.
Fátima FerreirinhaLaboratório de Farmacologia e Neurobiologia, Instituto de Ciências Biomédicas Abel Salazar - Universidade do Porto (ICBAS-UP), Porto, 4050-313, Portugal.
José MarinhasServiço de Ortopedia e Traumatologia, ULS Gaia- Espinho, Vila Nova de Gaia, 4434-502, Portugal.
Rolando FreitasServiço de Ortopedia e Traumatologia, ULS Gaia- Espinho, Vila Nova de Gaia, 4434-502, Portugal.
Rui LemosServiço de Ortopedia e Traumatologia, ULS Gaia- Espinho, Vila Nova de Gaia, 4434-502, Portugal.
Diogo CatelasServiço de Ortopedia, ULS de Santo António, Porto, 4099-001, Portugal.
Adélio VilaçaServiço de Ortopedia, ULS de Santo António, Porto, 4099-001, Portugal.
António OliveiraServiço de Ortopedia, ULS de Santo António, Porto, 4099-001, Portugal.
Paulo Correia-de-SáLaboratório de Farmacologia e Neurobiologia, Instituto de Ciências Biomédicas Abel Salazar - Universidade do Porto (ICBAS-UP), Porto, 4050-313, Portugal. farmacol@icbas.up.pt.ORCID http://orcid.org/0000-0002-6114-9189
José Bernardo Noronha-MatosLaboratório de Farmacologia e Neurobiologia, Instituto de Ciências Biomédicas Abel Salazar - Universidade do Porto (ICBAS-UP), Porto, 4050-313, Portugal. jbmatos@icbas.up.pt.ORCID http://orcid.org/0000-0001-6397-2104

Funding

Fundação para a Ciência e a Tecnologia EXPL/MED-FAR/1065/2021Fundação para a Ciência e a Tecnologia SFRH/BD/135942/2018Fundação para a Ciência e a Tecnologia SFRH/BD/144613/2019Fundação para a Ciência e a Tecnologia UIDP/04308/2020
6 · The paper itself

Abstract

backgroundParticipation of ADP-sensitive metabotropic P2Y

methodsPm BM-MSCs were cultured in an osteogenic-inducing medium in either the absence or presence of the selective P2Y

resultsBM-MSCs present immunoreactivity against all ADP-sensitive P2Y receptor subtypes, but their relative density varied among different Pm women and with the time of the cells in the culture. The P2Y

conclusionsThus, personalized offsetting the activity and/or expression of P2Y

Indexed as

Adenosine DiphosphateGene SilencingMesenchymal Stem CellsOsteogenesisPostmenopauseReceptors, Purinergic P2Receptors, Purinergic P2Y1Receptors, Purinergic P2Y12Cell DifferentiationCells, CulturedFemaleHumansMiddle AgedAdenosine DiphosphateP2RY13 protein, humanReceptors, Purinergic P2Receptors, Purinergic P2Y1Receptors, Purinergic P2Y12Cholesterol-rich lipid rafts/CaveolaMesenchymal stem cellsP2Y12 receptorP2Y13 receptorP2Y1 receptorPost-menopausal osteogenesis

Identifiers

PMID40713640
PMCPMC12291242

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.