ArticleJournal of cardiothoracic surgery2025
Association of outcome with non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio in hospitalized patients with congestive heart failure: a retrospective analysis.
Article in Journal of cardiothoracic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Prognostic value of admission NHHR for functional recovery in acute ischemic stroke.Frontiers in endocrinology · 2026Article
- Non-HDL-C/HDL-C Ratio and N-Terminal Pro-B-Type Natriuretic Peptide in the general and hospital-based population: a cross-sectional validation study.Frontiers in endocrinology · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the association between the Non-HDL cholesterol to HDL cholesterol ratio (NHHR) and all-cause mortality in patients with congestive heart failure (CHF) and to determine whether NHHR levels influence the prognosis of CHF patients.
methodsThe study participants were stratified based on the quartiles of NHHR. Kaplan-Meier (KM) curves, multivariate Cox regression analysis, and restricted cubic spline (RCS) analysis were employed to determine whether the prognosis of CHF patients varied according to NHHR levels.
resultsOur study included 2156 patients, of whom 274 (12.7%) died during hospitalization, 337 (15.6%) within 28 days, 480 (22.3%) within 90 days, and 665 (30.8%) within one year. Restricted cubic spline (RCS) analysis revealed a distinct U-shaped association between NHHR levels and mortality in CHF patients, characterized by an initial rapid decline followed by a gradual increase in mortality risk. Notably, patients in the lowest NHHR quartile (Q1) demonstrated significantly elevated 28-day, 90-day, and 1-year mortality rates (all P < 0.01, as confirmed by the Log-rank test) compared to the lower three quartiles, as confirmed by log-rank tests. Following the adjustment for confounding variables, multivariate Cox regression analysis established a substantial correlation between NHHR and all-cause mortality in CHF patients.
conclusionA virtually U-shaped link exists between NHHR and all-cause mortality in CHF patients, and further study is needed to corroborate this finding.
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