Evidence map›Paper›PMID 40713681›Full record

ArticleAIDS research and therapy2025

Long-term potassium monitoring and dynamics in risk of liver dysfunction among people living with HIV.

Hong Liu, Jiamin Li, Wenjun Ma, Xia Zhang, Jianfeng Bao, Jing Gao, Yujuan Zhang, Guoxiang Zheng, Dingyan Yan, Yue Zhang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS research and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hong Liu *Department of Pathology, Affiliated Hangzhou Xixi Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang province, China.
Jiamin Li *College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, Zhejiang province, China.
Wenjun MaDepartment of Hepatology, Affiliated Hangzhou Xixi Hospital, Zhejiang Chinese Medical University, Xihu District, 2 Hengbu Road, Hangzhou, Zhejiang province, 310023, China.
Xia ZhangDepartment of Open Laboratory, Affiliated Hangzhou Xixi Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang province, China.
Jianfeng BaoXixi Hospital Biobank, Affiliated Hangzhou Xixi Hospital, Zhejiang Chinese Medical University, Xihu District, 2 Hengbu Road, Hangzhou, Zhejiang province, 310023, China.
Jing GaoDepartment of Pathology, Affiliated Hangzhou Xixi Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang province, China.
Yujuan ZhangDepartment of Nursing, Affiliated Hangzhou Xixi Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang province, China.
Guoxiang ZhengDepartment of Nursing, Affiliated Hangzhou Xixi Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang province, China.
Dingyan YanDepartment of Nursing, Affiliated Hangzhou Xixi Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang province, China.
Yue ZhangXixi Hospital Biobank, Affiliated Hangzhou Xixi Hospital, Zhejiang Chinese Medical University, Xihu District, 2 Hengbu Road, Hangzhou, Zhejiang province, 310023, China.
Jinsong HuangXixi Hospital Biobank, Affiliated Hangzhou Xixi Hospital, Zhejiang Chinese Medical University, Xihu District, 2 Hengbu Road, Hangzhou, Zhejiang province, 310023, China. huangjinsongyz@126.com.
Yinhua NiCollege of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, Zhejiang province, China. shali0145@zjut.edu.cn.
Fang LiuXixi Hospital Biobank, Affiliated Hangzhou Xixi Hospital, Zhejiang Chinese Medical University, Xihu District, 2 Hengbu Road, Hangzhou, Zhejiang province, 310023, China. hzxxlf@outlook.com.

Funding

Science and Technology Development Plan Project of Hangzhou 20201203B191
6 · The paper itself

Abstract

backgroundLiver dysfunction, which serves as a critical indicator of advanced liver disease and a driver of mortality in PLWH, is frequently accompanied by perturbations in serum potassium homeostasis. This study aims to investigate the association between serum potassium and liver dysfunction in PLWH, with identifying potential indicative value for risk stratification of hepatic outcomes.

methodsA total of 2,725 PLWHs, with 10,718 measurements of serum potassium, were enrolled in this study. Piecewise linear mixed-effect model with smoothing function and Cox regression analysis were used to identify the association of serum potassium with liver dysfunction.

resultsA U-shaped relationship was identified between serum potassium and liver dysfunction, with a threshold of 4.25 mmol/L. Participants with baseline potassium > 4.25 mmol/L had a 27% (95% CI: 1.04–1.54) higher risk of mild liver dysfunction and a 48% (95% CI: 1.01–2.14) higher risk of severe liver dysfunction, which were confirmed by Kaplan-Meier analyses.

conclusionsThe study establishes serum potassium concentration as an independent predictor of liver dysfunction in PLWHs, highlighting the importance of potassium monitoring and management for this population.

Indexed as

HIV InfectionsLiver DiseasesPotassiumAdultFemaleHumansLiverMaleMiddle AgedRisk FactorsPotassiumHIVLiver dysfunctionSerum potassium

Identifiers

PMID40713681
PMCPMC12297841

What Socratic holds

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.