ArticleCardiovascular diabetology2025
Associations of cumulative exposure and dynamic trajectories of the C-reactive protein-triglyceride-glucose index with incident cardiovascular disease in middle-aged and older Chinese adults: a nationwide cohort study.
Article in Cardiovascular diabetology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
- Long-term cumulative exposure and change patterns of CTI-FI predict the risk of cardiometabolic multimorbidity in middle-aged and older Chinese adults.Journal of diabetes and metabolic disorders · 2026Article
- Composite C-reactive protein-triglyceride-glucose adiposity indices and incident cardiovascular-liver-metabolic multimorbidity: a prospective cohort study.Cardiovascular diabetology · 2026Article
- C-reactive protein-triglyceride-glucose index predicts postoperative delirium in older surgical patients: a retrospective cohort study.Lipids in health and disease · 2026Article
- Associations of C-Reactive Protein-Triglyceride Glucose Index and Estimated Pulse Wave Velocity With All-Cause Mortality: A Nationwide Prospective Cohort Study.Health science reports · 2026Article
- Association between C-reactive protein-triglyceride glucose index (CTI) and cardiovascular and all-cause mortality risk among the elderly population: insights from three datasets.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Association of high-sensitivity C-reactive protein-triglyceride glucose index and stroke outcomes: results from the China National Stroke Registry III.BMC neurology · 2026Article
- Prognostic value of C-reactive protein-triglyceride-glucose index in hospitalised patients with acute decompensated heart failure.BMC cardiovascular disorders · 2026Article
- C-reactive protein-triglyceride glucose index and its dynamic trajectories on all-cause mortality in critically ill children: a longitudinal, retrospective cohort study.Pediatric research · 2026Article
- Observational
- Associations of cumulative exposure and longitudinal change patterns of the triglyceride glucose-Chinese visceral adiposity index with incident cardiovascular disease in middle-aged and older adults: evidence from CHARLS.Cardiovascular diabetology · 2026Observational
- Association of glycolipid metabolism 6 factors index with cardiovascular and metabolic diseases, and its predictive value in disease progression.BMC endocrine disorders · 2026Article
- The synergistic pattern of metabolic-inflammatory changes jointly predicts cardiovascular risk in Chinese middle-aged and older adults: a prospective cohort study.Scientific reports · 2026Article
- Association of the C-reactive protein-triglyceride glucose index with new-onset myocardial infarction risk: a prospective cohort study.Scientific reports · 2026Article
- Association of the C-reactive protein-triglyceride-glucose (CTI) index and its central obesity-modified derivatives with incident cardiometabolic multimorbidity: results from two prospective cohorts in China and England.Cardiovascular diabetology · 2026Article
- Composite C-reactive protein-triglyceride-glucose-adiposity indices and incident cardiovascular disease in the CHARLS cohort: a prospective cohort study.Cardiovascular diabetology · 2026Article
- Associations of the combined C-reactive protein-triglyceride glucose index and frailty index in different dimensions with incident stroke among individuals with stages 0-3 cardiovascular-kidney-metabolic syndrome.Cardiovascular diabetology · 2026Article
- Correlation between the modified cardiometabolic index and the incidence of cardiovascular disease in a population with cardiovascular-kidney-metabolic syndrome stages 0-3: a nationwide prospective cohort study.Scientific reports · 2026Article
- Article
- Association of cumulative exposure and dynamic trajectories of the C-reactive protein-triglyceride-glucose and its modified indices with cardiovascular disease in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: a longitudinal analysis based on CHARLS.Cardiovascular diabetology · 2026Observational
- CHG index and ePWV jointly predict cardiovascular disease risk: findings from the CHARLS cohort.BMC cardiovascular disorders · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveThis study aimed to explore the relationships between cumulative C-reactive protein-triglyceride-glucose index (cuCTI) and CTI changes and the risk of new-onset cardiovascular disease (CVD) in middle-aged and older Chinese individuals.
methodsThis longitudinal study employed data from the China Health and Retirement Longitudinal Study. To evaluate the association between the cuCTI index and CVD risk, we conducted Cox regression analyses alongside restricted cubic spline (RCS) regression models. The participants were categorized into three groups on the basis of the dynamic changes in the CTI through K-means clustering. Subgroup analysis and sensitivity analysis were performed to confirm the robustness of the results.
resultsA total of 4157 participants were included in the study, of whom 609 (13.5%) were diagnosed with CVD. The incidence risk of CVD increased with increasing cuCTI. In fully adjusted Model 3, the Cox regression results indicated that, compared with those in Q1, participants in Q2 had a significantly greater risk of developing CVD (HR, 1.53 [1.22, 1.92], P
conclusionThis study revealed that cuCTI and changes in CTI are independently associated with the risk of CVD among middle-aged and elderly individuals with elevated cuCTI levels, particularly those with sustained high CTI levels, exhibited a significantly higher risk of CVD. As a cost-effective and accessible tool, cuCTI may provide supplementary information for assessing CVD risk. Monitoring long-term changes in the CTI and maintaining it at relatively low levels may aid early identification of individuals at high risk for CVD.
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