SynthesisJournal of orthopaedic surgery and research2025
Application and mechanism of percutaneous puncture disc platelet-rich plasma injection for lumbar disc herniation: a systematic review and meta-analysis.
Synthesis in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The efficacy and safety of endoscopic surgery combined with platelet-rich plasma for lumbar disk herniation: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Platelet-rich plasma (PRP) versus steroid as an intradiscal injection for lower back aches among degenerative disc disorder patient in India.Bioinformation · 2026Article
- [Research progress of hydrogel-based growth factors for treatment of intervertebral disc degeneration].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough platelet-rich plasma (PRP) has been increasingly used for the treatment of lumbar disc herniation (LDH), its effect on patient outcomes lacks systematic assessment. This study aimed to compare the effects of PRP treatment and other treatments in LDH patients using the Oswestry Disability Index (ODI) and two visual analog scales (VASs) via a meta-analysis.
methodsWe systematically searched relevant studies from the PubMed, Embase, and Cochrane Library databases from their inception to October 24, 2024. The visual analog scale of back pain (VAS-BP), visual analog scale of leg pain (VAS-LP), pooled VAS and ODI score data at 1, 3, 6, and 12 months after surgery were extracted. A fixed/random effects model was used for the meta-analysis. Sensitivity analysis was performed to explore the main sources of heterogeneity and investigate the robustness of the results.
resultsThis meta-analysis included 8 studies involving 697 patients. The results revealed that the ODI in the PRP group was significantly lower than that in the control group at most time points after surgery (P < 0.05). The VAS-BP score at 3 and 6 months after surgery, the VAS-LP score at 3, 6, and 12 months after surgery, and the pooled VAS score at the 3 months after surgery (P < 0.05) were significantly lower in the PRP group.
conclusionsIntradiscal PRP injection can significantly alleviate long-term pain and dysfunction in LDH patients, and its efficacy is greater than that of the control treatment; however, further studies are needed to verify the long-term mechanism involved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.