ArticleHuman genomics2025
A genome-wide pleiotropy study between atopic dermatitis and neuropsychiatric disorders.
Article in Human genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed.
- Atopic dermatitis and attention-deficit/hyperactivity disorder comorbidity in children and adolescents: Epidemiology, mechanisms, and clinical management.Pediatric investigation · 2026Review
- Plasma Metabolomic and Proteomic Profiling of the Mechanisms Underlying the Cumulative Impact of Co-occurring Psychiatric Disorders on Atopic Dermatitis.Acta dermato-venereologica · 2026Article
- Single-CellInternational journal of molecular sciences · 2026Article
- Gut-Brain Inflammation and Disrupted Homeostasis Due to Activation of Mast Cells and Microglia.International journal of molecular sciences · 2026Review
- Mendelian randomization studies in atopic dermatitis: causal insights across omics layers.Frontiers in immunology · 2026Review
- Shared Genetic Architecture Between Atopic Dermatitis and Autoimmune Diseases.International journal of molecular sciences · 2025Article
- Transcriptome-wide analyses delineate the genetic architecture of expression variation in atopic dermatitis.HGG advances · 2025Article
- Association between maternal anxiety/depression in pregnancy and the development of offspring eczema/AD: a meta-analysis based on cohort studies.Frontiers in pediatrics · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Atopic dermatitis (AD) frequently co-occurs with neuropsychiatric disorders, yet the genetic basis for this comorbidity is unclear. We performed a large-scale genome-wide pleiotropy approach to investigate the genetic correlations and causal associations between AD and five neuropsychiatric disorders, attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BP), major depressive disorder (MDD), and schizophrenia (SCZ). We identified significant positive genetic correlations between AD and ADHD, MDD and BP. Genome-wide pleiotropy scans identified 37 distinct pleiotropic loci, mapped in 86 unique genes participating in inflammatory pathways. Pleiotropy-informed target prioritization facilitated the identification of novel pathophysiological mechanisms for AD and putative drug targets, such as members of TNF and JAK-STAT3 signaling. Mendelian randomization provided evidence of a causal relationship between genetic liability to MDD and BP in increased AD risk, independent of sample overlap. Our findings elucidate immune-related pathway crosstalks between AD and neuropsychiatric disorders with implications for therapeutic interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.