Evidence map›Paper›PMID 40713878›Full record

ArticleParasites & vectors2025

Effects of maternal Echinococcus multilocularis infection on colitis susceptibility and gut microbiota of offspring.

Yihui Liu, Yang Xu, Yang Zou, Yingying Ding, Jiayun Zhang, Ying Zhang, Quanhai Pang, Shuai Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasites & vectors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yihui LiuCollege of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi, China.
Yang XuState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730000, Gansu, China.
Yang ZouState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730000, Gansu, China.
Yingying DingState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730000, Gansu, China.
Jiayun ZhangState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730000, Gansu, China.
Ying ZhangState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730000, Gansu, China.
Quanhai PangCollege of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi, China. pangquanhai@126.com.
Shuai WangState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730000, Gansu, China. wangshuai@caas.cn.

Funding

Gansu Provincial Natural Science Foundation No. 23JRRA1514National Natural Science Foundation of China No. 32172878Science and Technology Major Project of Gansu Province 23ZDNA007The Major Science and Technology Project of Gansu Province 22ZD6NA001The National Key Research and Development Program of China No. 2022YFD1800200The National Natural Science Foundation of China No. 32273089
6 · The paper itself

Abstract

backgroundMaternal immune modulation and alterations in gut microbiota due to intestinal helminth infections may be passed on to offspring. However, it remains unclear whether these effects can be transferred between maternal mice and their offspring during tissue-dwelling helminth infections.

methodsIn this study, we investigated the effect of maternal infection with Echinococcus multilocularis (Emu) on offspring susceptibility to colitis and gut microbiota composition using a dextran sulfate sodium (DSS)-induced colitis model. We performed 16S ribosomal RNA (rRNA) sequencing to analyze the gut microbiota composition and microbial abundance in Emu-infected and control maternal mice, as well as their offspring.

resultsWe found that the maternal mice infected with Emu exhibited significant resistance to colitis, characterized by increased expression of Foxp3 in colonic tissue. Conversely, this resistance phenotype was not observed in the offspring of Emu-infected maternal mice, as they showed no reduction in colitis severity and demonstrated decreased Foxp3 expression. Furthermore, the gut microbiota of Emu-infected maternal mice underwent significant changes, with an increase in genera such as Rikenella, Rikenellaceae RC9 gut group, Turicibacter, Odoribacter, and Parabacteroides, while Lactobacillus, Staphylococcus, and Bifidobacterium decreased postinfection. By contrast, their offspring exhibited a markedly distinct gut microbiota shift, characterized by significant increases in Candidatus Saccharimonas, Desulfovibrio, Helicobacter, and Odoribacter, alongside significant reductions in Muribaculum and Clostridium sensu stricto 1 when compared with the offspring of naive mice.

conclusionsThese findings suggest that the effects of maternal transmission concerning immune regulation and microbiota alterations in response to helminth infections may depend on species-specific factors.

Indexed as

ColitisEchinococcosisEchinococcus multilocularisGastrointestinal MicrobiomeAnimalsDisease Models, AnimalDisease SusceptibilityFemaleMiceMice, Inbred C57BLPregnancyRNA, Ribosomal, 16SRNA, Ribosomal, 16SColitis modelEchinococcus multilocularisFoxp3Gut microbiotaMaternal transmission

Identifiers

PMID40713878
PMCPMC12297764

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.