Trial reportThe Journal of allergy and clinical immunology2025
Cockroach immunotherapy modulates dominant T-cell responses independent of allergen extract content.
Trial report in The Journal of allergy and clinical immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
34 authors.
Funding
Abstract
backgroundT-cell responses to the individual components of allergen extracts have not been fully elucidated in subcutaneous allergen immunotherapy (SCIT). Specifically, it is unknown whether T-cell responses to immunodominant allergens are more or less sensitive to modulation, and whether allergen abundance in the immunotherapy extract influences T-cell response modulation.
objectiveTo fill these gaps, we evaluated CD4
methodsParticipants aged 8-17 years with mild-to-moderate, well-controlled asthma received 12 months' dosing with cockroach SCIT (n = 20) or placebo (n = 26). Peripheral blood mononuclear cells were isolated before and after 12 months of therapy. CD4
resultsSCIT modulation was more prominent in participants with the strongest and most T
conclusionImmunodominant responses are effectively modulated by SCIT, and this effect is independent of allergen abundance in the extract utilized for SCIT.
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