Evidence map›Paper›PMID 40714174›Full record

ArticleThe Journal of nutrition2025

Contrasting Effects of Phosphatidylcholine and Betaine Supplementation on Embryonic Development in a Mouse Model of the MTHFD1 R653Q Variant.

Karen E Christensen, Marie-Lou Faquette, Aaron T Gebert, Vafa Keser, Teodoro Bottiglieri, Rima Rozen

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In one paragraph

Article in The Journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Karen E ChristensenDepartments of Human Genetics and Pediatrics, McGill University, Montreal, Quebec, Canada; The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
Marie-Lou FaquetteDepartments of Human Genetics and Pediatrics, McGill University, Montreal, Quebec, Canada; The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
Aaron T GebertCenter of Metabolomics, Institute of Metabolic Disease, Baylor Scott and White Research Institute, Dallas, TX, United States.
Vafa KeserDepartments of Human Genetics and Pediatrics, McGill University, Montreal, Quebec, Canada; The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
Teodoro BottiglieriCenter of Metabolomics, Institute of Metabolic Disease, Baylor Scott and White Research Institute, Dallas, TX, United States.
Rima RozenDepartments of Human Genetics and Pediatrics, McGill University, Montreal, Quebec, Canada; The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada. Electronic address: rima.rozen@mcgill.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFolate and choline are interconnected nutrients important for embryonic development. Genetic variants in folate enzymes, such as MTHFD1 R653Q (c.1958 G>A, rs2236225), may increase dietary choline requirements.

objectivesTo evaluate the impact of phosphatidylcholine or betaine supplementation on embryonic development and maternal choline metabolism in the Mthfd1S

methodsFemale Mthfd1S

resultsPtdCho increased developmental delays, compared with Ctrl, in litters of WT (170%) and HET (125%) mothers (P

conclusionsPhosphatidylcholine and betaine supplementation had contrasting effects on reproductive outcomes. PtdCho increased developmental delays. BTN reduced delays and defects in the Mthfd1S

Indexed as

BetaineDietary SupplementsEmbryonic DevelopmentFormate-Tetrahydrofolate LigaseMethylenetetrahydrofolate Dehydrogenase (NADP)PhosphatidylcholinesAnimalsCholineFemaleFolic AcidMaternal Nutritional Physiological PhenomenaMethenyltetrahydrofolate CyclohydrolaseMiceMultifunctional EnzymesPregnancyBetaineCholineFolic AcidFormate-Tetrahydrofolate LigaseMethenyltetrahydrofolate CyclohydrolaseMethylenetetrahydrofolate Dehydrogenase (NADP)Mthfd1 protein, mouseMultifunctional EnzymesPhosphatidylcholinesbetainecholinedevelopmental defectsdevelopmental delayembryoMTHFD1neural tube defectsphosphatidylcholine

Identifiers

PMID40714174
PMCPMC12799447

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.