ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2025
In Vivo Study of Bone Growth Around Additively Manufactured Implants With Ti-6Al-4V and Bioactive Glass Powder Composites.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Human mesenchymal stem cell differentiation on bioactive glass-coated implants.Bioinformation · 2026Article
- Editorial: Translational development of tailored implants via advanced processing and surface modifications for tissue regeneration.Frontiers in bioengineering and biotechnology · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Effective osseointegration is a fundamental requirement in biomedical implant applications. Additive manufacturing allows precise control over implant geometry and material composition, enhancing implant design flexibility. Bioactive glass (BG) can substantially enhance bone binding and bioactivity; however, limited research has been conducted on its incorporation into additively manufactured implants. The performance of BG varies depending on the incorporation method, and the spatial and temporal evolution of its integration remains unclear. In this study, we synthesized Ti-6Al-4V/58S BG composites by using the selective laser melting method and systematically compared the effects of BG coating and doping in additively manufactured implants. In vivo histological results from animal tests were statistically analyzed and discussed in terms of osseointegration over 4- and 12-week periods. Bone-to-implant contact (BIC) and bone density (BD) were used as quantitative metrics to evaluate interactions between the implants and surrounding bone. Our findings indicate that both BG-doped and BG-coated implants accelerated bone ingrowth during the early stages of healing. BG-coated implants demonstrated a greater improvement than did pure 3D-printed Ti-6Al-4V implants. However, the effects of BG became nonsignificant during the later healing stage (12 weeks). This study provides a foundation for systematically investigating BG incorporation methods in 3D-printed biomedical implants and their effect on osseointegration.
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Registered trials
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