Evidence map›Paper›PMID 40715366›Full record

ArticleNPJ precision oncology2025

Multimodal prediction based on ultrasound for response to neoadjuvant chemotherapy in triple negative breast cancer.

Maohua Lyu, Shouheng Yi, Chunyan Li, Yu Xie, Yu Liu, Zeyan Xu, Zhitao Wei, Huan Lin, Yunlin Zheng, Chunwang Huang and 5 more

Abstract read
In one paragraph

Article in NPJ precision oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Maohua Lyu *Department of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Shouheng Yi *School of Electronic Engineering, Xi'an Shiyou University, Xi'an, China.
Chunyan Li *Department of Ultrasound, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Yu Xie *Department of Radiology, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Peking University Cancer Hospital, Yunnan, China.
Yu LiuGuangdong Provincial Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application, Guangzhou, China.
Zeyan XuDepartment of Radiology, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Peking University Cancer Hospital, Yunnan, China.
Zhitao WeiGuangdong Provincial Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application, Guangzhou, China.
Huan LinDepartment of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Yunlin ZhengDepartment of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Chunwang HuangDepartment of Ultrasound, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Xi LinDepartment of Ultrasound, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Zaiyi LiuDepartment of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China. liuzaiyi@gdph.org.cn.
Shufang PeiDepartment of Ultrasound, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China. peishufang@gdph.org.cn.
Biao HuangDepartment of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China. huangbiao@gdph.org.cn.
Zhenwei ShiDepartment of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China. shizhenwei@gdph.org.cn.

Funding

Guangdong Provincial Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application 2022B1212010011National Natural Science Foundation of China 82102034National Natural Science Foundation of China 82171955the Key-Area Research and Development Program of Guangdong Province 2021B0101420006the Natural Science Foundation of Guangdong Province of China 2024A1515011672
6 · The paper itself

Abstract

Pathological complete response (pCR) can guide surgical strategy and postoperative treatments in triple-negative breast cancer (TNBC). In this study, we developed a Breast Cancer Response Prediction (BCRP) model to predict the pCR in patients with TNBC. The BCRP model integrated multi-dimensional longitudinal quantitative imaging features, clinical factors and features from the Breast Imaging Data and Reporting System (BI-RADS). Multi-dimensional longitudinal quantitative imaging features, including deep learning features and radiomics features, were extracted from multiview B-mode and colour Doppler ultrasound images before and after treatment. The BCRP model achieved the areas under the receiver operating curves (AUCs) of 0.94 [95% confidence interval (CI), 0.91-0.98] and 0.84 [95%CI, 0.75-0.92] in the training and external test cohorts, respectively. Additionally, the low BCRP score was an independent risk factor for event-free survival (P < 0.05). The BCRP model showed a promising ability in predicting response to neoadjuvant chemotherapy in TNBC, and could provide valuable information for survival.

Identifiers

PMID40715366
PMCPMC12297240

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.