ArticleScientific reports2025
Mechanism exploration of di(2-ethylhexyl) phthalate (DEHP)-induced breast cancer via network toxicology and molecular docking analysis.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- The Endocrine Disrupting Compounds Bisphenol-A and α-Zeranol Mimic the Estrogen Transcriptional Program to Promote Proliferation and Stemness in Breast Cancer Cells.Molecular carcinogenesis · 2026Article
- Network toxicology deciphers micro- and nanoplastics-mediated mixture hazard, predictive risk assessment, and regulatory translation.Archives of toxicology · 2026Review
- Article
- Revealing key biomarkers and molecular mechanisms associated with di(2-ethylhexyl) phthalate in skin cancer.Frontiers in molecular biosciences · 2026Article
- Unveiling the mechanistic links between plasticizers and gastric cancer via network toxicology and molecular docking approaches.BMC pharmacology & toxicology · 2025Article
- Bibliometric and visual analysis of global research on endocrine-disrupting chemicals and children's health: evidence, emerging concerns, and research gaps.Global health action · 2025Article
- Network Toxicology and Molecular Docking Reveal the Toxicological Mechanisms of DEHP in Bone Diseases.International journal of molecular sciences · 2025Article
- Phthalates and epigenetics: An emerging public health concern.Current research in toxicology · 2025Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Disease caused by plasticizers has received increasing attention. Di(2-ethylhexyl) phthalate (DEHP), one of the most widely exposed plasticizers, has been shown to be closely associated with the development of breast cancer (BRCA) in epidemiological studies, but the specific mechanistic targets and related pathways are still unclear. In this study, we aimed to elucidate the potential pathogenic targets and mechanisms of DEHP-induced BRCA through network toxicology and molecular docking. Databases including GeneCards, OMIM, ChEMBL, and SwissTargetPrediction were first used to identify DEHP-related targets and BRCA-related targets, and 691 potential targets were obtained from the intersection analysis. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to clarify the biological functions and pathways of potential targets. Protein-protein interaction (PPI) analysis revealed the interactions between potential targets, and 14 hub targets of DEHP-induced BRCA were further screened. To verify the clinical significance of the hub targets, the expression of the target proteins was verified in the TCGA database, and the affinity between DEHP and 12 key targets (hub targets with p < 0.05) was determined via molecular docking. Our study provides a theoretical basis for DEHP-induced BRCA from the "Homo sapiens" perspective and reveals the potential risks caused by exposure to DEHP, thus providing new strategies for the prevention and treatment of DEHP-induced BRCA.
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