SynthesisOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2025
Fatty acid dietary intakes and blood concentrations in relation to hip fracture risk in adults: a systematic review and meta-analysis of prospective cohort studies.
Synthesis in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Association of low-carbohydrate-diet score and osteoporotic fractures: National Health and Nutrition Examination Survey.Frontiers in public health · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous research suggests that dietary intake and blood levels of fatty acids may influence the risk of osteoporosis and hip fractures, although findings have been inconsistent. We conducted a meta-analysis of nine prospective cohort studies involving 382,094 participants and 12,392 hip fractures to investigate these associations. Follow-ups ranged from 7 to 24 years in duration. A hazard ratio (HR) of 1.20 (95% CI: 1.08-1.33) indicated that a higher intake of saturated fatty acids (SFAs) was associated with an increased risk of hip fractures. In contrast, polyunsaturated fatty acids (PUFAs) (HR: 0.93; 95% CI: 0.85-1.00) and linoleic acid (LA) (HR: 0.89; 95% CI: 0.82-0.96) were associated with a lower risk, though the PUFA association was marginal. The inverse relationship for LA was observed only at intakes of 9-16 g per day. Higher amounts of PUFAs (HR: 0.75; 95% CI: 0.61-0.92), total omega-3 fatty acids (HR: 0.79; 95% CI: 0.64-0.97), and eicosapentaenoic acid (EPA) (HR: 0.76; 95% CI: 0.62-0.94) in the blood were linked to a lower risk. No significant associations were found for other fatty acids. These findings suggest that consuming 9-16 g of linoleic acid (LA) daily (equivalent to 2-3 tablespoons of corn oil or 30-60 g of walnuts) and maintaining elevated blood levels of omega-3 fatty acids, especially eicosapentaenoic acid (EPA), may help reduce the risk of hip fractures.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.