ReviewInternational journal of obesity (2005)2025
Heart-guarding or heart-harming? The dual role of epicardial adipose tissue in cardiovascular health and disease.
Review in International journal of obesity (2005), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Oxidative Stress in Diabetic Cardiomyopathy: Molecular Mechanisms and Emerging Therapeutic Targets.Biomolecules · 2026Review
- Association between region-specific epicardial adipose tissue and CT-derived fractional flow reserve-defined myocardial ischemia: a retrospective coronary CTA study stratified by hypertension and type 2 diabetes mellitus.Frontiers in medicine · 2026Article
- Epicardial adipose tissue as a metabolically active visceral fat depot: an emerging target in cardiovascular disease.Frontiers in cardiovascular medicine · 2026Review
- Immuno-inflammatory-metabolic interactions in cardiovascular diseases: a review from basic mechanisms to clinical translation.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epicardial adipose tissue (EAT), nestled directly against the beating heart, is a fascinating paradox in cardiovascular biology. In health, this unique fat depot functions as a metabolic ally and immune modulator, safeguarding the heart through energy support, anti-inflammatory actions, and mechanical cushioning. Yet, under pathological conditions, EAT transforms from a protective "heart-guardian" into a destructive "heart-harmer," releasing pro-inflammatory mediators, driving oxidative stress, and fueling cardiovascular diseases like coronary artery disease (CAD) and atrial fibrillation (AF). This review explores EAT's dual role, unraveling its complex biology and the delicate balance between protection and pathology. We delve into its cellular and molecular intricacies, highlight its pivotal contributions to cardiovascular health and disease, and synthesize cutting-edge research to illuminate its clinical relevance. By identifying current knowledge gaps and proposing future directions, we aim to inspire a deeper understanding of EAT and its potential as a therapeutic target. As we navigate this duality, EAT emerges as both a challenge and an opportunity in the quest to better understand and treat cardiovascular diseases.
Indexed as
Identifiers
40715762What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.