Evidence map›Paper›PMID 40715766›Full record

ArticleThe EMBO journal2025

YTHDF3 recognizes DNA N6-methyladenine and recruits ALKBH1 for 6mA removal from genomic DNA.

Xin-Hui Chen, Zi-Lu Wang, Jincui Yang, Min Chen, Si-Yi Zhao, Kun-Xiong Guo, Xuelong Zheng, Zhengwei Zhao, Xiaoqiang Chen, Jing Li and 5 more

Abstract read
In one paragraph

Article in The EMBO journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. A DNA-Based Binding Assay for the mChembiochem : a European journal of chemical biology · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xin-Hui Chen *Biomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, 510150, Guangzhou, China.ORCID http://orcid.org/0000-0002-3644-2674
Zi-Lu Wang *Biomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, 510150, Guangzhou, China.
Jincui Yang *Biomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, 510150, Guangzhou, China.
Min Chen *Biomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, 510150, Guangzhou, China.ORCID http://orcid.org/0009-0002-7655-1768
Si-Yi ZhaoBiomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, 510150, Guangzhou, China.
Kun-Xiong GuoBiomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, 510150, Guangzhou, China.
Xuelong ZhengBiomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, 510150, Guangzhou, China.
Zhengwei ZhaoBiomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, 510150, Guangzhou, China.
Xiaoqiang ChenBiomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, 510150, Guangzhou, China.
Jing LiBiomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, 510150, Guangzhou, China.ORCID http://orcid.org/0009-0000-5381-6087
Min-Min ZhangBiomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, 510150, Guangzhou, China.
Ling RanBiomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, 510150, Guangzhou, China.
Huifang ZhuBiomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, 510150, Guangzhou, China.
Xiao-Feng GuBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, 100081, Beijing, China. guxiaofeng@caas.cn.ORCID http://orcid.org/0000-0003-1127-4261
Guang-Rong YanBiomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, 510150, Guangzhou, China. tgryan@jnu.edu.cn.ORCID http://orcid.org/0000-0003-4859-8710

Funding

MOST | National Natural Science Foundation of China (NSFC) 32450743MOST | National Natural Science Foundation of China (NSFC) 82125029MOST | National Natural Science Foundation of China (NSFC) 82341016Science and Technology Projects in Guangzhou 2023A03J0390
6 · The paper itself

Abstract

DNA N

Indexed as

AdenineAlkB Homolog 1, Histone H2a DioxygenaseDNARNA-Binding ProteinsAnimalsDNA MethylationHumansAdenineALKBH1 protein, humanAlkB Homolog 1, Histone H2a DioxygenaseDNARNA-Binding ProteinsALKBH1dsDNAGenomic 6mA ReaderGenomic DNA 6mAYTHDF3

Identifiers

PMID40715766
PMCPMC12402098

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.