ArticleDiscover oncology2025
Jet lag-induced circadian disruption elevates glioma risk by altering molecular profiles in distinct brain regions.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
Abstract
purposeTo investigate the mechanism underlying chronic jet lag (CJL)-induced circadian disruption stimulating glioma-related gene expression across distinct brain regions, and to examine the regulatory role of core clock genes in modulating neural oncogenic susceptibility.
methodsThis experiment was initiated with the establishment of an animal model of CJL (6-h light-cycle advances every 2 days for 10 or 30 days) in wild-type and clock gene-deficient mice (Bmal1
resultsCJL induced brain region-specific dysregulation of oncogenic pathways, with marked activation of oncogenes (C-MYC↑, and MDM-2↑) in hypothalamic and striatal regions, while suppression of tumor suppressors (GADD45A↓, and p53↓) in hippocampal and cortical regions. Clock gene mutations amplified these effects, particularly in Bmal1
conclusionChronic circadian disruption acts as a brain region-specific oncogenic stressor, driving transcriptional reprogramming of cancer pathways in a clock gene-dependent manner. Mechanistically, our study may establish a relationship of circadian dysfunction with glioma risk, underscoring the necessity for sex-stratified chronotherapeutic approaches in neuro-oncology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.