ArticleApplied biochemistry and biotechnology2025
Exploration of Antidiabetic and Anti-Apoptotic Activity of Cissus quadrangularis Stem Through Mechanistic Pathway: An in vitro, in silico and in vivo Approach.
Article in Applied biochemistry and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Effects ofMedicina (Kaunas, Lithuania) · 2025Trial
- Article
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7 authors.
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Abstract
In the twenty-first century, across the world, there are few ethnomedical solutions for treating type 2 diabetes mellitus (T2DM), a common metabolic disease and its associated disorders. The present study assessed the hypoglycaemic effects of an extract from the stem of Cissus quadrangularis in a rat model with the addition of in vitro and in silico investigations specifically α-amylase, α-glucosidase inhibitory tests and molecular docking, molecular dynamics (MD) simulation study. Streptozotocin and nicotinamide were used to generate type 2 diabetes in rats. Thereafter, Cissus quadrangularis (CQ) stem extract was given orally for 28 days at doses of 200 and 400 mg/kg body weight. The extract improved biochemical indicators, lowered lipid peroxidation, raised HDL levels, and decreased blood glucose in a dose-dependent manner. Tissue healing in treated groups was confirmed by histopathological examination. The α-amylase and α-glucosidase inhibition assays had respective IC
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