Evidence map›Paper›PMID 40716776›Full record

ArticleNucleic acids research2025

SMUG1 DNA glycosylase modulates reward behaviour through regulation of olfactory receptor gene expression.

Diana L Bordin, Yohan Lefol, Maria J Largartos-Donate, Nicola P Montaldo, Veslemøy Rolseth, Nuriye B Tekin, Lisa Lirussi, Christine Gran Neurauter, Yan Liu, Yahyah Aman and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nucleic acids research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Diana L BordinDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Nordbyhagen 1474, Norway.ORCID 0000-0002-6518-0466
Yohan LefolDepartment of Microbiology, Oslo University Hospital and University of Oslo, Oslo 0424, Norway.
Maria J Largartos-DonateDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Nordbyhagen 1474, Norway.
Nicola P MontaldoDepartment of Microbiology, Oslo University Hospital and University of Oslo, Oslo 0424, Norway.ORCID 0000-0003-3434-615X
Veslemøy RolsethDepartment of Microbiology, Oslo University Hospital and University of Oslo, Oslo 0424, Norway.
Nuriye B TekinDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Nordbyhagen 1474, Norway.
Lisa LirussiDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Nordbyhagen 1474, Norway.
Christine Gran NeurauterDepartment of Microbiology, Oslo University Hospital and University of Oslo, Oslo 0424, Norway.
Yan LiuDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Nordbyhagen 1474, Norway.
Yahyah AmanDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Nordbyhagen 1474, Norway.
Rajikala SuganthanDepartment of Microbiology, Oslo University Hospital and University of Oslo, Oslo 0424, Norway.
Antonio SarnoDepartment of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim 7491, Norway.
Tianjiao ZhangFaculty of Health Sciences, University of Macau, E12 University Avenue, Taipa, Macau, China.
Lene AlsøeDepartment of Microbiology, Oslo University Hospital and University of Oslo, Oslo 0424, Norway.
Junbai WangDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Nordbyhagen 1474, Norway.ORCID 0000-0001-5505-5613
Magnar BjøråsDepartment of Microbiology, Oslo University Hospital and University of Oslo, Oslo 0424, Norway.ORCID 0000-0001-8759-1170
Garry WongFaculty of Health Sciences, University of Macau, E12 University Avenue, Taipa, Macau, China.ORCID 0000-0003-4566-9958
Hilde NilsenDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Nordbyhagen 1474, Norway.ORCID 0000-0003-2115-2663

Funding

Norwegian Cancer Society 295901South-Eastern Norway Regional Health Authority 2019098The Research Council of Norway 14477
6 · The paper itself

Abstract

The SMUG1 DNA glycosylase is the primary enzyme responsible for excising 5-hydroxymethyluracil (5hmU) from genomic DNA. SMUG1 activity is high in the brain, suggesting its crucial role in controlling 5hmU levels in this organ. 5hmU has been proposed as an epigenetic mark, but it is still unclear whether, and in which contexts, it may have regulatory functions. Here we show that accumulation of 5hmU in Smug1-deficient mice leads to widespread gene expression alterations across multiple brain regions. Chromatin immunoprecipitation revealed that SMUG1 is recruited to AT-rich promoters of olfactory receptor genes, where it regulates 5hmU levels. The persistence of 5hmU in the olfactory receptor promoters leads to deficits in sensory perception of smell and influences reward-related behaviour. Thus, we identify a specific function for SMUG1 in promoting transcription of olfactory receptor genes.

Indexed as

Gene Expression RegulationReceptors, OdorantRewardUracil-DNA GlycosidaseAnimalsBrainMiceMice, Inbred C57BLMice, KnockoutPromoter Regions, GeneticSmellReceptors, OdorantUracil-DNA Glycosidase

Identifiers

PMID40716776
PMCPMC13223739

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.