Evidence map›Paper›PMID 40717441›Full record

ArticleJournal of Alzheimer's disease : JAD2025

The differential relationship between white matter cerebrovascular perfusion and microstructure between normal cognition and mild cognitive impairment.

Donghoon Kim, Sarah Yoon, Timothy M Hughes, Yu-Chien Wu, Danielle Harvey, Megan E Lipford, Samuel N Lockhart, Suzanne Craft, Laura D Baker, Christopher T Whitlow and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Donghoon KimDepartment of Biomedical Engineering, University of California, Davis, Davis, CA, USA.ORCID 0000-0002-5479-2707
Sarah YoonDepartment of Radiology, University of California, Davis, Sacramento, CA, USA.ORCID 0009-0006-9261-1846
Timothy M HughesDepartment of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0002-2919-7199
Yu-Chien WuDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0003-1084-2634
Danielle HarveyDepartment of Public Health Sciences, University of California, Davis, Davis, CA, USA.ORCID 0000-0002-5367-0951
Megan E LipfordDepartment of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0003-1357-2131
Samuel N LockhartDepartment of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0002-0893-5420
Suzanne CraftDepartment of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0003-0591-8657
Laura D BakerDepartment of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0002-6217-7384
Christopher T WhitlowDepartment of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0003-2392-8293
Stephanie E Okonmah-ObazeeDepartment of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Christina E HugenschmidtDepartment of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0002-9126-7565
Matthew BobinskiDepartment of Radiology, University of California, Davis, Sacramento, CA, USA.ORCID 0000-0002-8349-2084
Youngkyoo JungDepartment of Biomedical Engineering, University of California, Davis, Davis, CA, USA.ORCID 0000-0002-7236-8897

Funding

Wake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUZANNE CRAFT · 2021 to 2026
$24.3M
The relationship between early signs of small vessel disease and diffuse white matter disease through imaging biomarkers among people with risk of cognitive decline.RF1NS110043 · NINDS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI JUNG, YOUNGKYOO · 2018 to 2018
$1.9M
NIA NIH HHS P30 AG072947NINDS NIH HHS RF1 NS110043
6 · The paper itself

Abstract

BackgroundMild cognitive impairment (MCI) has been related to impairment in cerebrovascular perfusion and microstructural magnetic resonance imaging (MRI) parameters. However, the relationship between cerebrovascular perfusion and microstructure remains understudied, especially within normal-appearing white matter (NAWM).ObjectiveThis study aimed to investigate the differential relationship between white matter cerebrovascular perfusion and microstructure between normal cognition (NC) and MCI using multiple MRI measurements within NAWM.MethodsWe examined differences between 24 MCI and 55 NC participants in NAWM for cerebrovascular perfusion and microstructural measures, including cerebrovascular reactivity (CVR), cerebral blood flow, arterial transit time (ATT), and intracellular volume fraction (ICVF), isotropic volume fraction, and orientation dispersion index in models adjusted for vascular risk factors including hypertension, glycemic status, and the presence of

Indexed as

Cerebrovascular CirculationCognitionCognitive DysfunctionWhite MatterAgedAged, 80 and overBrainFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsAlzheimer's diseasemagnetic resonance imagingmild cognitive impairmentneuroimagingperfusion imagingwhite matter

Identifiers

PMID40717441
PMCPMC12583654

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.