ArticleChemical science2025
Electrochemical synthesis of aziridines, pyrrolidines and oxazolines enabled by azo-free alcohol amination.
Article in Chemical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Oxetane-to-azetidine skeletal editing.Nature chemistry · 2026Article
- Electrochemical control enables high-concentration, one-pot macrolactonization.Chemical science · 2026Article
- Electrochemical Halogenation and Etherification of Alcohols Enabled by a Halide-Coupled Phosphine Oxidation.ACS organic & inorganic Au · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although amines and nitrogen-containing heterocycles are prominent scaffolds in bioactive compounds, functional materials, and commodity chemicals, their synthesis and functionalization often suffer from lengthy pre-installation of the appropriate functional groups, employing exotic amination/aziridination reagents and the use of expensive or toxic catalysts. Herein, we developed a mild and economical electrochemical amination method to access aziridine, pyrrolidine and oxazoline motifs from the corresponding amino alcohol substrates. Compared to the classic Mitsunobu reaction, this method exhibits an expanded scope of nucleophiles, including weakly acidic amides and primary amines. Mechanistic studies provided direct evidence for the proposed two-electron oxidation of alcohol and PPh
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Registered trials
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