ArticleFrontiers in nutrition2025
Association between changes in the triglyceride glucose-body roundness Index and cardiovascular disease risk in middle-aged and elderly Chinese adults: a nationwide longitudinal study from 2011 to 2015.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Association between insulin resistance surrogate markers and cardiovascular disease risk in individuals with subclinical metabolic disorders: a prospective cohort study based on baseline levels, cumulative exposure, and longitudinal trajectories.Cardiovascular diabetology · 2026Article
- Joint associations of anthropometric indices and C-reactive protein-triglyceride-glucose index with incident hypertension: a stratified analysis by blood pressure level from the CHARLS, 2011-2020.Cardiovascular diabetology · 2026Article
- Association of the atherogenic index of plasma combined with obesity indices with cardiovascular disease and mortality.Lipids in health and disease · 2026Article
- Association between the triglyceride glucose index:Chinese visceral adiposity index (TyG-CVAI) and new-onset cardiovascular disease in middle-aged and older adults-insights from the China Health and Retirement Longitudinal Study (CHARLS).Cardiovascular diabetology · 2026Article
- Association of the triglyceride glucose-body roundness index with mortality in HFpEF and effect modification by nutritional status: a multicenter prospective cohort study.Lipids in health and disease · 2025Article
- Assessment of cholesterol-HDL-glucose index in anticipating risk of cardiometabolic diseases: a comparative study with triglyceride-glucose index.Scientific reports · 2025Article
- Associations of longitudinal trajectories of triglyceride-glucose index combined with classical and novel obesity indices and cardiovascular disease: evidence from a nationwide prospective cohort study in China.Cardiovascular diabetology · 2025Observational
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Abstract
Background: Cardiovascular disease (CVD) is a major global health issue. The triglyceride-glucose (TyG) index, a marker of insulin resistance, and the body roundness index (BRI), reflecting visceral adiposity, are key risk factors for chronic diseases. However, research on the long-term impact of changes in obesity and metabolic markers on CVD risk is limited. This study examines the association between long-term changes in the TyG-BRI composite index and CVD incidence in middle-aged and older Chinese adults. Methods: Data were obtained from the China Health and Retirement Longitudinal Study, which included 4,446 middle-aged and elderly from 2011 to 2015. The participants were classified into three clusters based on TyG-BRI changes by K-means clustering method. Logistic regression analyses and restricted cubic spline (RCS) regression analyses were used to assess the association between the TyG-BRI and CVD incidence. Receiver operating characteristic (ROC) curves were generated to compare the predictive accuracy of the TyG-BRI, TyG, and BRI. Results: By the end of 2015, 1,007 participants (22.6%) had developed CVD. The incidence of CVD increased progressively across TyG-BRI clusters. After adjusting for multiple covariates, logistic regression analysis revealed a significant correlation between the TyG-BRI and the onset of CVD [odds ratio, 95% confidence interval: 1.251 (1.139-1.373) per 1 SD increase]. The RCS regression analysis revealed a significant positive and linear relationship between the TyG-BRI and CVD incidence ( Conclusion: Long-term variations in the TyG-BRI index are closely associated with CVD risk, demonstrating superior predictive performance compared to using BRI or TyG alone. Our findings offer new insights into the interplay between metabolic dysfunction and cardiovascular risk. TyG-BRI may serve as a more effective auxiliary tool for CVD risk assessment and provides valuable guidance for the early identification of high-risk populations.
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