SynthesisFrontiers in nutrition2025
Leptin, CRP, and adiponectin correlate with body fat percentage in adolescents: systematic review and meta-analysis.
Synthesis in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Platelet Indices and Adipokines in Adults with Long-Standing Type 1 Diabetes.Journal of clinical medicine · 2026Article
- Understanding the mechanisms underlying obesity induced tumorigenesis: therapeutic perspectives to manage dysregulated lipid metabolism.Discover oncology · 2026Review
- Fish Oil Alters the Metabolome, Antioxidative Potential, and Secretory Profile of Visceral Adipose Tissue in Mice with High-Fat Diet-Induced Obesity Compared with Other Dietary Fat Sources.Molecules (Basel, Switzerland) · 2026Article
- Acute Effects of Exercise on Metabolic, Inflammatory, and Immune Markers in Adolescent Girls with Normal Weight or Overweight/Obesity.Sports (Basel, Switzerland) · 2026Article
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Adipose tissue is important in the secretion of inflammatory substances, and may be directly or indirectly associated to the development of cardiovascular and metabolic diseases in adolescence. Objective: To evaluate whether inflammatory markers are associated to body fat percentage in adolescents. Methodology: Systematic review conducted following the items of the PRISMA, and registered in PROSPERO. The descriptors adolescent, body fat distribution and cytokines were combined together in the electronic databases: Scopus, PubMed, Embase, Cochrane, Scholar Google and ProQuest, independently by two researchers, in January 2022 and atualized in November 2024. Meta-analysis of the correlation of inflammatory markers with body fat percentage was conducted using the metabin function of the meta package of the RStudio software (4.0.4). Results: Resulted in 7,592 records, of which 31 articles met the inclusion criteria and were selected for this study. Cross-sectional and prospective cohort observational studies were included. The meta-analysis included 4,682 adolescents, aged 10 to 19 years, of both sexes. The inflammatory markers leptin and C-reactive protein were positively correlated ( Conclusion: In adolescents, the body fat percentage is related to the inflammatory markers leptin, C-reactive protein and adiponectin. It is important to evaluate the body fat composition of adolescents in clinical practice to identify those with a higher percentage of fat, that may reflect an inflammatory profile, as well as increased cardiometabolic risk that accompanies adolescents into adulthood. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42020208305, identifier PROSPERO: CRD42020208305.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.