ArticleJournal of hepatocellular carcinoma2025
Survival Benefit of Adjuvant Treatment with Huaier Granules Plus Lenvatinib in Hepatocellular Carcinoma Patients with Tumors Greater Than 5 cm After Radical Hepatectomy.
Article in Journal of hepatocellular carcinoma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Integrating Network Pharmacology and Experimental Validation to Elucidate the Role of Huaier in Attenuating Liver Fibrosis via the AKT Signalling Pathway.Clinical and experimental medicine · 2026Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The postoperative recurrence of hepatocellular carcinoma (HCC), influenced by various factors, including microvascular invasion (MVI), plays a critical role in the long-term prognosis following radical liver resection. This study investigated potential adjuvant treatment strategies for HCC patients who exhibit multiple recurrence factors after radical resection. Methods: A retrospective analysis was conducted on data from 243 patients who underwent radical resection for HCC and exhibited high recurrence factors at the First Affiliated Hospital of Harbin Medical University. Some of these patients received postoperative adjuvant therapy with Huaier granules, lenvatinib, or a combination of both, while others did not receive any postoperative adjuvant therapy. Results: Survival analysis showed a more favorable prognosis in the adjuvant Huaier granules and lenvatinib groups (all P < 0.05). Furthermore, when compared to monotherapy, the combination therapy group exhibited significantly improved overall survival (OS) (P = 0.001) and disease-free survival (DFS) (P = 0.001). Multivariate Cox regression analysis demonstrated that the addition of Huaier granules to lenvatinib was an independent protective factor associated with improved OS (hazard ratio (HR) = 0.777, 95% confidence interval (CI) = 0.616-0.980, P = 0.033) and DFS (HR = 0.753, 95% CI = 0.615-0.920, P = 0.006). Conclusion: In this retrospective analysis, the combination of Huaier granules and lenvatinib as postoperative adjuvant therapy was associated with improved long-term prognosis in patients at high risk of HCC recurrence.
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