SynthesisFrontiers in neurology2025
Efficacy and safety of vitamin E as adjunctive therapy for epilepsy: a systematic review and meta-analysis of randomized control trials.
Synthesis in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and safety of antioxidants and dietary therapies for epilepsy: an umbrella meta-analysis.Frontiers in nutrition · 2025Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Vitamin E, functioning as an antioxidant, holds substantial potential in the adjuvant treatment of epilepsy. However, it remains uncertain whether the existing evidence is adequate to validate the use of vitamin E as an add-on therapy for improving epilepsy outcomes. The aim of this study was to explore the efficacy and safety of vitamin E as an adjuvant treatment for epilepsy. Methods: We searched PubMed, Embase, the Cochrane Library, and Chinese databases including the Chinese Biomedicine Literature Database, China National Knowledge Infrastructure, Chinese Sci-tech Journal Database, Wanfang Data for eligible studies from inception to February 28, 2025. Meta-analysis was performed to calculate the risk ratio (RR) and weighted mean difference (WMD) of the included randomized controlled trials (RCTs). Results: Among the 2,348 records obtained, 11 RCTs involving 824 patients were included after literature screening. Vitamin E had a potential advantage in reducing seizure frequency by >75% (RR = 1.73, 95% confidence interval (CI) (1.31, 2.28), Conclusion: Vitamin E shows potential as adjunctive therapy, particularly in pediatric populations, with acceptable safety profile, but high-quality trials are required to confirm its efficacy and safety.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.