Hypertension mediates the association between weight-adjusted waist index and new onset stroke risk in middle-aged and older Chinese adults: evidence from the CHARLS study.

Background: The weight-adjusted waist index (WWI) serves as a novel body metric for evaluating abdominal adiposity. However, the association between WWI and stroke risk across varying blood pressure statuses remains poorly understood. Methods: This study included 12,580 individuals aged 45 and above with no prior stroke incidents, drawn from the China Health and Retirement Longitudinal Study (CHARLS) between 2011 and 2020. Multiple analytical approaches were utilized to assess the relationship linking WWI and incident stroke, including Cox proportional hazards regression, restricted cubic splines, subgroup analyses, and sensitivity analyses. The predictive capacity of WWI for stroke was evaluated through receiver operating characteristic (ROC) curves, with further stratification based on blood pressure status and other anthropometric indicators. A mediation approach was employed to investigate the intermediary role of hypertension in the WWI-stroke association. Results: The investigation recruited 12,580 participants, 727 (5.78%) experienced stroke events. Across all Cox regression models, increased WWI consistently demonstrated a significant association with elevated stroke risk (HR = 1.12, 95%CI: 1.02-1.22, Conclusion: This study revealed that elevated WWI levels independently contribute to a higher stroke occurrence rate in middle-aged and older adult demographics, with a particularly pronounced effect observed in hypertensive individuals.