Evidence map›Paper›PMID 40718352›Full record

ReviewOsteoporosis and sarcopenia2025

Sarcopenia prevention in older adults: Effectiveness and limitations of non-pharmacological interventions.

Doyoon Kim, Satoru Morikawa, Masashi Miyawaki, Taneaki Nakagawa, Sumito Ogawa, Yoshitaka Kase

Abstract readReview
In one paragraph

Review in Osteoporosis and sarcopenia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Nutrients · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Doyoon KimKeio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Satoru MorikawaDepartment of Dentistry and Oral Surgery, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Masashi MiyawakiDepartment of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Taneaki NakagawaDepartment of Dentistry and Oral Surgery, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Sumito OgawaDepartment of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yoshitaka KaseDepartment of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sarcopenia is characterized by a decline in skeletal muscle mass, strength, and physical performance in older adults and is associated with reduced quality of life, an increased risk of requiring long-term care, and a significant economic burden on both patients and their families. In the context of global population aging, sarcopenia presents substantial health and social challenges. However, no effective pharmacological treatment has been established to date, and current management relies on non-pharmacological interventions. This review provides an overview of the most recent evidence on exercise, nutrition, and electrical muscle stimulation (EMS) as strategies to prevent the onset and progression of sarcopenia and discusses their effectiveness and limitations. Although the effectiveness of resistance training, alone or in combination with multicomponent exercise, has been demonstrated, the benefits of nutritional interventions and EMS remain limited. From a pathophysiological perspective, chronic inflammation has been identified as a key contributor to sarcopenia progression and is increasingly considered a potential therapeutic target. This review underscores the significance of a comprehensive intervention strategy tailored to the needs of the older population.

Indexed as

Chronic inflammationNon-pharmacological interventionsOlder adultsSarcopenia

Identifiers

PMID40718352
PMCPMC12288930

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.