ReviewDiabetes, metabolic syndrome and obesity : targets and therapy2025
The Emerging Role of Anti-Hyperglycemic Agents for the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease.
Review in Diabetes, metabolic syndrome and obesity : targets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Lysophosphatidic acid-induced Arf6-driven macropinocytosis of CD147International journal of biological sciences · 2026Article
- Beyond diabetes and obesity: GLP-1 receptor agonists as multifunctional therapeutics across the steatotic liver disease spectrum.Frontiers in pharmacology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of type 2 diabetes mellitus (T2D) and metabolic dysfunction-associated steatotic liver disease (MASLD) is rapidly increasing worldwide. MASLD, previously known as non-alcoholic fatty liver disease (NAFLD), is defined as a condition of steatotic liver disease (SLD) with one or more cardiometabolic risk factor(s) and the absence of harmful alcohol intake. The variety of MASLD includes steatosis, metabolic dysfunction-associated steatohepatitis (MASH, formerly NASH), fibrosis, cirrhosis and MASH-related hepatocellular carcinoma (HCC). Subjects with T2D have a doubled risk of developing MASLD, and vice versa. Furthermore, the presence of T2D is considered a risk factor for cirrhosis, hepatocellular carcinoma and liver-related mortality in patients with MASLD as well as the presence of MASLD is associated with adverse outcomes in T2D population, including cardiovascular and chronic kidney diseases. The relationship between MASLD and T2D is bidirectional. Given the fact that a mutually detrimental relationship between T2D and MASLD exists, the approach to managing MASLD is undergoing a transformative phase, with increasing attention toward the use of anti-hyperglycemic agents. In this review, we explore the emerging role of anti-hyperglycemic agents in the context of MASLD treatment, examining the latest scientific evidence and assessing the effectiveness of these novel approaches. Understanding the interconnection between diabetes and MASLD could open new therapeutic perspectives and guide the formulation of more effective treatment protocols for this growing metabolic epidemic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.