Evidence map›Paper›PMID 40718731›Full record

ArticleBioactive materials2025

Shape memory bone screws loading L-arginine and Ca

Huaqian Liu, Weiwei Zhao, Yuhe Yang, Ho-Pan Bei, Qunchao Chen, Xintong Zhou, Yuanchi Zhang, Chunyi Wen, Yuefeng Hao, Jinlian Hu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Huaqian LiuDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, 999077, China.
Weiwei ZhaoDepartment of Biomaterials, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, Shandong, 250012, China.
Yuhe YangDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, 999077, China.
Ho-Pan BeiDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, 999077, China.
Qunchao ChenOrthopedics and Sports Medicine Center, The Affiliated Suzhou Hospital of Nanjing Medical University, 215006, China.
Xintong ZhouDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, 999077, China.
Yuanchi ZhangCentre for Translational Medicine Research & Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Chunyi WenDepartment of Biomedical Engineering, the Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, 999077, China.
Yuefeng HaoOrthopedics and Sports Medicine Center, The Affiliated Suzhou Hospital of Nanjing Medical University, 215006, China.
Jinlian HuDepartment of Biomedical Engineering, City University of Hong Kong, Hong Kong SAR., 999077, China.
Yaxiong LiuSchool of Mechatronic Engineering and Automation, Foshan University, Foshan, 528225, China.
Yu ZhangMedical Research Center, Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
Ka-Hing WongResearch Institute for Future Food, Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, 999077, China.
Hongyu ZhangState Key Laboratory of Tribology in Advanced Equipment, Department of Mechanical Engineering, Tsinghua University, Beijing, 100084, China.
Xin ZhaoDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, 999077, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metallic bone screws are clinically used to fix the fractured bone fragments in bone defect treatment; yet they present compromised therapeutic efficacy due to poor osseointegration and tissue support. Here, we develop a novel thermoresponsive shape memory (SMP) bone screw with osteogenesis-angiogenesis coupling for enhanced bone regeneration. The SMP bone screws are prepared by die casting of shape memory polyurethane/hydroxyapatite (PU/HA) composite, coated with L-arginine (Arg) and calcium ions (Ca

Indexed as

Bone screwsCalcium signaling pathwayNO-cGMP signaling pathwayOsteogenesis-angiogenesis couplingShape memory effect

Identifiers

PMID40718731
PMCPMC12296549

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.