Evidence map›Paper›PMID 40718787›Full record

SynthesisPeerJ2025

Effects of soy isoflavones on menopausal symptoms in perimenopausal women: a systematic review and meta-analysis.

Haodi Luan, Qianqian Liu, Yahui Guo, Hua Fan, Sileng A, Jing Lin

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Haodi LuanClinical Nutrition Department, Critical Care Medicine Department, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Qianqian LiuDepartment of Gastroenterology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Yahui GuoClinical Nutrition Department, Critical Care Medicine Department, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Hua FanClinical Nutrition Department, Critical Care Medicine Department, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Sileng AMedical Simulation Center, Inner Mongolia Medical University, Hohhot, China.
Jing LinClinical Nutrition Department, Critical Care Medicine Department, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Soy isoflavones are phytoestrogens found mainly in soy and its derivatives. Given their estrogen-like and antioxidant-inhibiting inflammatory effects, they have been hypothesized to be effective in treating menopausal symptoms. We conducted a systematic review in accordance with the PRISMA guidelines. In October 2024, we screened 2,099 articles, of which 12 were eligible for meta-analysis, and found that soy isoflavones were effective for treating menopausal symptoms (seven studies, 533 participants, Hedges' g = -0.25, 95% CI [-0.42 to -0.08],

Indexed as

Glycine maxIsoflavonesMenopausePerimenopausePhytoestrogensDepressionFemaleHot FlashesHumansMiddle AgedIsoflavonesPhytoestrogensClimactericHot flushMenopauseMeta-analysisPhytoestrogensSoy isoflavones

Identifiers

PMID40718787
PMCPMC12296567

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.