ReviewFrontiers in molecular biosciences2025
Review of research progress in sepsis-associated acute kidney injury.
Review in Frontiers in molecular biosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Lactate in acute kidney injury: pathobiology, risk stratification, and clinical interpretation.Renal failure · 2026Review
- Pharmacological activation of SIRT1 alleviates sepsis-associated acute kidney injury by improving renal mitochondrial energy metabolism.Renal failure · 2026Article
- Pediatric sepsis-associated acute kidney injury: leveraging pathophysiology for risk stratification and identification of treatable traits.Pediatric nephrology (Berlin, Germany) · 2026Review
- Gallic acid attenuates LPS-induced acute kidney injury with accompanying changes in inflammatory and redox-related signaling pathways.Molecular biology reports · 2026Article
- Recent advances in stimuli-responsive nanomaterials for the treatment of acute kidney injury.Journal of nanobiotechnology · 2026Review
- Biomarker-Based Diagnosis and Risk Stratification in Sepsis-Associated Acute Kidney Injury: From Molecular Mechanisms to Multimarker Panels.Diagnostics (Basel, Switzerland) · 2026Review
- Eryptosis in Acute Patients: A Hypothesis on Its Potential Clinical Impact and Current Gaps in Evidence.Current issues in molecular biology · 2026Review
- Crosstalk between innate immune signaling pathways and integrated TLR, NLRP3 inflammasome, cGAS-STING, and NF-κB networks in sepsis.Frontiers in cell and developmental biology · 2026Review
- Development and validation of a temporal staging-based nomogram for 1-year mortality in sepsis-associated acute kidney injury.Frontiers in cellular and infection microbiology · 2026Article
- Identification of common diagnostic biomarkers and immune landscapes in sepsis and acute kidney injury: a transcriptomic study integrating machine learning and single-cell analysis.Frontiers in genetics · 2026Article
- Early recognition of sepsis-associated acute kidney injury based on BioBERT-BPNN multimodal clinical data analysis.PloS one · 2026Article
- Early Clinical, Laboratory, and Imaging Correlates of Neurological Dysfunction in Adults Presenting to the Emergency Department with Sepsis: A Single-Center Retrospective Study.Juntendo medical journal · 2026Article
- Predicting the acute pancreatitis severity with multi-machine learning models: constructing an online prediction platform.Frontiers in cellular and infection microbiology · 2026Article
- Cell and extracellular vesicle therapies for AKI in critical care: clinical translation, organ-support integration, and lessons learned.Frontiers in medicine · 2026Review
- Multi-omics analysis reveals neutrophil heterogeneity and key molecular drivers in sepsis-associated acute kidney injury.Frontiers in immunology · 2025Article
- Article
- Exploring the Role of Microbiota-Mediated Gut-Kidney Axis in Acute Kidney Injury: Immunomodulation and Therapy.Kidney diseases (Basel, Switzerland)Review
- Growth Differentiation Factor 15 (GDF15) Protects Against Sepsis-Associated Acute Kidney Injury via Suppression of TLR4-MyD88-NF-κB Signaling and Ferroptosis.BioFactors (Oxford, England)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis-associated acute kidney injury (SAAKI) poses a significant challenge in critical care medicine, characterized by high morbidity and mortality rates and often leading to chronic kidney disease (CKD). This article provides a comprehensive overview of the pathophysiological mechanisms, diagnostic advancements, therapeutic strategies, and prognostic studies of SAAKI. In terms of pathophysiological mechanisms, research has shifted from the traditional renal ischemia-centric view to a multidimensional interplay involving microcirculatory disturbances, immune metabolic disorders, and programmed cell death. Regarding diagnosis, traditional Kidney Disease: Improving Global Outcomes (KDIGO) criteria exhibit limitations, whereas novel biomarkers and imaging techniques offer new avenues for early diagnosis. Therapeutic strategies encompass early intervention, hemodynamic management, renal replacement therapy, and targeted therapies; however, controversy persists regarding the optimal timing and methods of their initiation. Prognostic studies focus on the mechanisms underlying the transition from SAAKI to CKD and corresponding preventive strategies. Future research should bridge the gap between animal models and human pathology and explore the potential of multi-omics technologies and artificial intelligence in optimizing management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.