Evidence map›Paper›PMID 40719301›Full record

ArticleMicrobiology spectrum2025

A study on the transcriptional characteristics of novel HERV gene in the blood of children with Kawasaki disease and its correlation with the disease.

Yan Lu, Minli Yuan, Juan Xu, Mengxu Yi, Xingyu Mo, Ying Zhu, Shanjie Wei, Peiting Yang, Chenglin Zhou, Wen Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yan Lu *Department of Pediatrics, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, China.ORCID 0009-0005-7031-638X
Minli Yuan *Department of Pediatrics, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, China.ORCID 0009-0006-9782-2941
Juan XuClinical Laboratory Center, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, China.
Mengxu YiDepartment of Pediatrics, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, China.
Xingyu MoDepartment of Pediatrics, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, China.
Ying ZhuDepartment of Pediatrics, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, China.
Shanjie WeiDepartment of Pediatrics, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, China.
Peiting YangDepartment of Microbiology, School of Medicine, Jiangsu University, Zhenjiang, China.
Chenglin ZhouClinical Laboratory Center, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, China.ORCID 0000-0003-2661-2067
Wen ZhangDepartment of Microbiology, School of Medicine, Jiangsu University, Zhenjiang, China.ORCID 0000-0002-9352-6153
Hongyan LuDepartment of Pediatrics, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, China.ORCID 0000-0002-8876-5328

Funding

National Key Research and Development Program of China 2022YFC2603801National Natural Science Foundation of China 82341106Science and Technology Bureau of Zhenjiang SS2023012Science and Technology Support Program of Jiangsu Province M2022043
6 · The paper itself

Abstract

Human endogenous retroviruses (HERVs), integral to the human genome, are implicated in autoimmune diseases through superantigen-mediated vascular inflammation. This study examined NCBI next-generation sequencing blood transcriptome data from 62 pairs of children with acute Kawasaki disease (KD) and healthy controls. Bioinformatics analysis identified differentially expressed HERV gene sequences (|Log

Indexed as

Endogenous RetrovirusesMucocutaneous Lymph Node SyndromeChildChild, PreschoolComputational BiologyFemaleHigh-Throughput Nucleotide SequencingHumansInfantMalePhylogenyTranscription, GeneticTranscriptomeendogenous retrovirushumankawasaki diseasephylogenetic analysis

Identifiers

PMID40719301
PMCPMC12403589

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.