Evidence map›Paper›PMID 40719369›Full record

SynthesisOmics : a journal of integrative biology2025

Clinical and Genetic Predictors of Sickle Cell Nephropathy: A Global Systematic Review.

Kambe Banda, Arthemon Nguweneza, Khuthala Mnika, Victoria Nembaware, George Chagaluka, Ambroise Wonkam

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Omics : a journal of integrative biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kambe BandaDivision of Human Genetics, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Arthemon NguwenezaDivision of Human Genetics, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Khuthala MnikaDivision of Human Genetics, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Victoria NembawareDivision of Human Genetics, Department of Pathology, University of Cape Town, Cape Town, South Africa.
George ChagalukaDepartment of Paediatrics and Child Health, Kamuzu University of Health Sciences (KUHes), Blantyre, Malawi.
Ambroise WonkamDivision of Human Genetics, Department of Pathology, University of Cape Town, Cape Town, South Africa.

Funding

Sickle Africa Data Coordinating CenterU24HL135600 · NHLBI · UNIVERSITY OF CAPE TOWN · PI MULDER, NICOLA, WONKAM, AMBROISE · 2017 to 2025
$8.6M
NHLBI NIH HHS U24 HL135600
6 · The paper itself

Abstract

Sickle cell disease (SCD) affects nearly 300,000 newborns annually worldwide, with 80% born in Africa. Sickle cell nephropathy (SCN) affects 5-18% of patients with SCD and contributes significantly to morbidity and mortality. Identifying SCN-associated factors would promote effective clinical management. We conducted a global systematic review in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines (Prospective Register of Systematic Reviews, registration number: CRD42020185763) to explore clinical and genetic correlates of SCN. We sought after cohort, case-control, and cross-sectional studies published up to December 31, 2024 that reported on clinical and/or genetic predictors of SCN in different populations globally. A total of 70 hospital-based study articles were finally included, with a leading percentage (45.7%) of the included studies performed in the United States, whereas 24.3% were from Sub-Saharan Africa. Most had a cross-sectional design (68.6%) involving children and adults. Genetic studies (17/70) identified associations with α-thalassemia,

Indexed as

Anemia, Sickle CellKidney DiseasesApolipoprotein L1Genetic Predisposition to DiseaseGenome-Wide Association StudyHeme Oxygenase-1HumansAPOL1 protein, humanApolipoprotein L1Heme Oxygenase-1genetic predictorskidneynephropathyrisk factorssickle cell diseasesystematic review

Identifiers

PMID40719369
PMCPMC13577597

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.