Evidence map›Paper›PMID 40719656›Full record

ArticleTurk patoloji dergisi2025

Gabapentin-Induced Sub-Chronic Neurotoxicity in Rats and the Protective Role of Alpha-Tocopherol.

Mohammad Abd-El-Same'e El-Kattan, Eman Saeed, Mahmoud Ahmed Khattab, Fatma Maksoud, Maha Emad Eldein, Nada Elsayed Abdel-Roaf, Walaa Awad, Ahmed Elshatory

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Article in Turk patoloji dergisi, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohammad Abd-El-Same'e El-KattanDepartment of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Mansoura University, MANSOURA, EGYPT.
Eman SaeedDepartment of Medical Histology and Cell Biology, Faculty of Medicine, Mansoura University, MANSOURA, EGYPT.
Mahmoud Ahmed KhattabDepartment of medical pharmacology, Faculty of Medicine, Cairo University, CAIRO, EGYPT.
Fatma MaksoudDepartment of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, CAIRO, EGYPT.
Maha Emad EldeinDepartment of Pathology, Faculty of Medicine, Cairo University, CAIRO, EGYPT.
Nada Elsayed Abdel-RoafDepartment of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Cairo University, CAIRO, EGYPT.
Walaa AwadClinical Pharmacy Department, Abo El-Reesh Al Mounira Hospital, Cairo University, CAIRO, EGYPT.
Ahmed ElshatoryKuwait Poison Control Center, Ministry of health, KUWAIT CITY, KUWAIT.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe past ten years have seen an increase in gabapentin (GBP) overuse and abuse in Egypt after pregabalin scheduling. Numerous studies have demonstrated the detrimental effects of pregabalin; nonetheless, GBP`s effects are minimal. The objective of this investigation is to study GBP-induced neurotoxicity in rats and the protective benefits of alpha-tocopherol (vitamin E `Vit E`). MATERIAL AND

methodsForty (40) adult male albino rats were randomly split into four groups: (10 rats each): Group I, which was subdivided into group Ia (5 rats), received a regular diet as a negative control; group Ib (5 rats) received corn oil as a positive control; group II received alpha-tocopherol; group III (GBP misuse); and group IV received GBP + alpha-tocopherol. The corresponding medicines were administered to every rat for fifty days. Neurobehavioral tests were performed on the day of scarification. Hippocampal tissues were collected for immunohistochemical and histological analysis.

resultsWeight gain rose considerably by the end of the research in the drug-treated groups. In neurobehavioral tests, controls performed better and had higher locomotor indices. The group that misused GBP showed more deteriorated cells and more negative effects on hippocampal tissues. These histological alterations dramatically decreased with alpha-tocopherol therapy.

conclusionGBP in high doses had neurotoxic effects, disrupted hippocampal tissues, and increased the number of degenerated cells. Alpha-tocopherol treatment significantly attenuated the deleterious effects induced by GBP.

Indexed as

alpha-TocopherolAminesAntioxidantsCyclohexanecarboxylic Acidsgamma-Aminobutyric AcidHippocampusNeuroprotective AgentsNeurotoxicity SyndromesAnimalsBehavior, AnimalGabapentinMaleRatsRats, Wistaralpha-TocopherolAminesAntioxidantsCyclohexanecarboxylic AcidsGabapentingamma-Aminobutyric AcidNeuroprotective Agents

Identifiers

PMID40719656
PMCPMC12527561

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.