ArticleActa paediatrica (Oslo, Norway : 1992)2025
Predicted Adult Height Remained Normal in Children With Premature Adrenarche Despite Advanced Bone Age.
Article in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Determinants of pubertal progression and final height in premature pubarche.Journal of endocrinological investigation · 2026Article
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3 authors.
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Abstract
aimAetiological factors affecting the phenotype of adrenarche are largely unknown. This study investigated the phenotypic variability of premature adrenarche.
methodsIn this cross-sectional retrospective registry study, data on 91 mainly Caucasian children diagnosed with premature adrenarche were retrieved from patient records. Hormonal and growth-related variables were analysed, and the data were further divided into subgroups to explore variations in different phenotypes of premature adrenarche.
resultsWe studied 91 children with premature adrenarche (23% boys) with median ages of 7.5 years (range 4.5-8.9) for boys and 6.8 years (4.3-8.0) for girls. They displayed increased height and weight, elevated androgen levels, and clinical signs of androgen action. Bone age was advanced by approximately 1 year, with overweight children showing more advanced bone age and linear growth. Adult heights predicted with bone age were comparable to mean parental heights. Girls with more advanced bone age had higher dehydroepiandrosterone sulfate (DHEAS) levels. Interestingly, early (< 6 years) diagnosed children exhibited higher height standard deviation scores but lower DHEAS levels compared to those diagnosed later (≥ 6 years).
conclusionsDespite advanced bone age, predicted adult heights remained normal in premature adrenarche. Subgroup differences suggested the heterogeneity of aetiological factors in premature adrenarche.
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