ArticleTalanta2026
A method for simultaneous analysis of urinary melatonin, cortisol, and their metabolites using liquid chromatography tandem mass spectrometry and relevance of biomonitoring of these hormones in circadian rhythm.
Article in Talanta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Analytical Methods for Melatonin Quantification: Advances, Challenges, and Clinical Applications.Pharmaceuticals (Basel, Switzerland) · 2026Review
- The impact of sound intervention on sleep quality and stress levels in college students: a randomized controlled trial.Frontiers in psychology · 2026Article
- Mental health within ESG frameworks: a narrative and descriptive cross-national analysis.Frontiers in public health · 2026Review
- Effects of nocturnal melatonin-based tissue-bone homeostasis manipulation at varying time points on pain and central mechanisms in individuals with knee osteoarthritis: a randomized controlled trial.Frontiers in bioengineering and biotechnology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Circadian rhythm (CR) in humans regulates the physical and mental changes that take place following rhythmic shifts of light and darkness. Dysregulation of CR is related to sleep disorders and other health problems including immune suppression, cancer, neurological and cardiovascular diseases. The two main hormones that maintain a balance to control the sleep-wake cycles are melatonin (MEL) and cortisol (COR). Here we describe a novel environmentally friendly low-density solvent-dispersive liquid-liquid microextraction-ultra-performance liquid chromatography-tandem mass spectrometry (LDS-DLLME-UPLC-MS/MS) method for simultaneous quantification of MEL, COR and their metabolites: 2-hydroxymelatonin (2-HMEL), 6-hydroxymelatonin (6-HMEL), cyclic-3-hydroxymelatonin (3-cHMEL), N-γ-acetyl-5-methoxykynurenamine (AMK), N-acetyl-N-formyl-5-methoxykynuramine (AFMK), N-acetylserotonin (NAS), 6-sulfatoxy melatonin (SaMT), 6-hydroxycortisol (6-HCOR), cortisol sulfate (CORS), cortisone (CON), β-cortol (CO) and β-cortolone (COL) in urine. Chemometrics approaches were applied for method optimization. The method was validated with the recovery of target analytes at 100 %, precision <16 % RSD and the absence of matrix effects. The method limits of quantification (LOQs) were from 0.013 ng mL
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.