Evidence map›Paper›PMID 40721041›Full record

ArticleNeuropharmacology2025

In vitro and in vivo pharmacological characterization of fentanyl analogs.

Samuel Obeng, Kyle R Urquhart, Saki Fukuda, Victoria L C Pallares, Lance R McMahon, William E Fantegrossi, Takato Hiranita

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Antinociceptive Effect and Hyperalgesia of Fentanyl and Its Analogues.International journal of molecular sciences · 2026
    Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Samuel ObengDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA.
Kyle R UrquhartDepartment of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
Saki FukudaDepartment of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
Victoria L C PallaresDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA.
Lance R McMahonDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA.
William E FantegrossiDepartment of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA. Electronic address: WEFantegrossi@uams.edu.
Takato HiranitaDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA. Electronic address: hiranita@uthscsa.edu.

Funding

Gabapentinoid/opioid mixtures: abuse and toxicityR01DA058018 · NIDA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Takato Hiranita · 2023 to 2026
$1.7M
NIDA NIH HHS R01 DA058018
6 · The paper itself

Abstract

Opioid overdose is the leading cause of unintentional drug-related deaths in the United States (US), largely due to the use of illicitly manufactured synthetic opioids like fentanyl and its analogs. The pharmacological properties of novel fentanyl analogs are largely unknown. Thus, this study characterized opioid-like activities of six novel fentanyl analogs (acryl fentanyl, β-hydroxythio fentanyl, cyclohexyl fentanyl, 4-fluoroisobutyrly fentanyl, furanyl fentanyl, and tetrahydrofuranyl fentanyl) in vitro and in vivo, in comparison to morphine and fentanyl. In radioligand binding assays using [

Indexed as

Analgesics, OpioidFentanylAnimalsCHO CellsCricetinaeCricetulusDose-Response Relationship, DrugEnkephalin, Ala(2)-MePhe(4)-Gly(5)-Guanosine 5'-O-(3-Thiotriphosphate)HumansMaleMiceMorphineReceptors, Opioid, muAnalgesics, OpioidEnkephalin, Ala(2)-MePhe(4)-Gly(5)-FentanylGuanosine 5'-O-(3-Thiotriphosphate)MorphineReceptors, Opioid, muAddictionAntinociceptionDrug discriminationFentanyl analogsLocomotor activityOpioid overdosePrecipitated withdrawal

Identifiers

PMID40721041
PMCPMC12408109

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.