ReviewProceedings of the Japan Academy. Series B, Physical and biological sciences2025
Clones in blood and stratified epithelial cells, and their drivers.
Review in Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
1 author.
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Abstract
The term "clone" is commonly used in the medical and life sciences to denote a genetically identical population, at both the individual and cellular levels. The concept of clonal expansion is of fundamental importance in cancer research. The advent of advanced sequencing technologies has elucidated the clonal nature of intermediates between normal cells and cancer cells. This review underscores seminal discoveries in the blood and stratified squamous epithelial systems, emphasizing the pivotal role of mutations in DNA modifier genes and Notch pathway genes, respectively, as drivers of clonal expansion. Despite the distinct nature of these systems and their genetic backgrounds, a common biological principle emerges.
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Registered trials
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